Document Detail

Postnatal development of arterial pressure: influence of the intrauterine environment.
MedLine Citation:
PMID:  12715275     Owner:  NLM     Status:  MEDLINE    
A substantial number of epidemiological studies have shown that small size at birth is associated with an increased risk of developing hypertension and metabolic dysfunction later in life; however these associations have not been found in all studies. In animals, several models have been used to investigate the effects of perturbations to the fetal environment on later arterial pressure, with differing effects on size at birth and arterial pressure. Ovine models include maternal dietary manipulations, antenatal glucocorticoid exposure, and restriction of placental size and function. In our laboratory, we have induced late gestational placental insufficiency and growth restriction in sheep by umbilico-placental embolisation; during the early postnatal period the growth restricted lambs remained small and were hypotensive relative to controls. More recent long-term studies indicate that these growth restricted animals were able to catch up in body weight within the first postnatal year; however, their arterial pressure remained lower than that of controls throughout the first 2 postnatal years (deltaMAP, -4.2 +/- 1.4 mmHg). This relative hypotension may be due to altered vascular or cardiac development resulting from increased vascular resistance or nutrient restriction during fetal life. As late gestational placental insufficiency led to a persistent reduction in arterial pressure from birth to adulthood, our findings do not support the hypothesis that restricted fetal growth per se leads to hypertension after birth. It is likely that the effects of a prenatal compromise on postnatal arterial pressure will vary depending on the nature of the associated developmental perturbations and their gestational timing.
S Louey; M L Cock; R Harding
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Archives of physiology and biochemistry     Volume:  111     ISSN:  1381-3455     ISO Abbreviation:  Arch. Physiol. Biochem.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-04-25     Completed Date:  2003-11-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9510153     Medline TA:  Arch Physiol Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  53-60     Citation Subset:  IM    
Department of Physiology, Monash University, Victoria, Australia.
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MeSH Terms
Animals, Newborn
Birth Weight / genetics,  physiology
Blood Pressure / genetics,  physiology*
Body Weight / physiology
Cardiovascular Diseases / embryology,  genetics
Disease Models, Animal
Fetal Growth Retardation / genetics,  physiopathology*
Gestational Age
Glucocorticoids / physiology
Maternal Nutritional Physiological Phenomena / physiology
Placental Insufficiency / embryology,  etiology
Reg. No./Substance:

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