Document Detail

Postnatal development of the actual and total activity of the branched-chain 2-oxo acid dehydrogenase complex in rat tissues.
MedLine Citation:
PMID:  3569650     Owner:  NLM     Status:  MEDLINE    
Actual and total activities of the branched-chain 2-oxo acid dehydrogenase complex were determined in homogenates of quadriceps muscle, heart, liver, kidney and brain from rats of 0-70 days age. All rat tissues except quadriceps muscle showed a marked increase of total activity between 0 and 21 days, heart and kidney also after weaning. The actual activity rose after birth in liver, kidney and brain and after weaning in liver, kidney and heart. The activity state was always about 100% in liver and varied between 40-60% in kidney and brain, 10-23% in heart and 6-12% in quadriceps muscle. The actual activities measured indicate, that the degradation of branched-chain 2-oxo acids mainly takes place in the liver of the newborn, suckling and young-adult rat.
J H Veerkamp; A J Wagenmakers
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The International journal of biochemistry     Volume:  19     ISSN:  0020-711X     ISO Abbreviation:  Int. J. Biochem.     Publication Date:  1987  
Date Detail:
Created Date:  1987-06-15     Completed Date:  1987-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0250365     Medline TA:  Int J Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  205-7     Citation Subset:  IM    
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MeSH Terms
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
Aging / metabolism*
Animals, Newborn
Animals, Suckling
Brain / enzymology
Ketone Oxidoreductases / metabolism*
Kidney / enzymology
Liver / enzymology
Multienzyme Complexes / metabolism*
Muscles / enzymology
Myocardium / enzymology
Rats, Inbred Strains
Reg. No./Substance:
0/Multienzyme Complexes; EC 1.2.-/Ketone Oxidoreductases; EC Dehydrogenase (Lipoamide)

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