Document Detail

Postnatal development of action potential-induced dendritic calcium entry in neocortical layer II/III pyramidal cells.
MedLine Citation:
PMID:  10375666     Owner:  NLM     Status:  MEDLINE    
By whole-cell patch-clamp recording and calcium imaging with fura-2, we investigated postnatal development of intracellular calcium dynamics in apical dendrites of layer II/III pyramidal cells in the rat visual cortex. Dendritic calcium increases, induced by single action potentials, occurred only slightly on postnatal days 8-10 (P8-10), and then underwent a gradual enhancement during the second postnatal week to become 2-3-fold larger on P16-18 than on P8-10. The results suggest that the developmental growth of calcium dynamics may play a critical role for functional development of neocortical neurons.
Y Isomura; K Yamamoto; K Hashimoto; N Kato
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  832     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-08-18     Completed Date:  1999-08-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  175-8     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Elsevier Science B.V.
Department of Integrative Brain Science, Graduate School of Medicine, Kyoto University, 606-8501, Kyoto, Japan.
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MeSH Terms
Action Potentials / physiology
Analysis of Variance
Calcium / metabolism*
Dendrites / metabolism*
Neocortex / growth & development,  physiology*
Patch-Clamp Techniques
Pyramidal Cells / physiology*
Rats, Wistar
Reg. No./Substance:

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