| Postnatal deficiency of essential fatty acids in mice results in resistance to diet-induced obesity and low plasma insulin during adulthood. | |
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MedLine Citation:
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PMID: 21177089 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Our objective was to investigate the long-term metabolic effects of postnatal essential fatty acid deficiency (EFAD). Mouse dams were fed an EFAD diet or an isoenergetic control diet 4 days before delivery and throughout lactation. The pups were weaned to standard diet (STD) and were later subdivided into two groups: receiving high fat diet (HFD) or STD. Body composition, energy expenditure, food intake and leptin levels were analyzed in adult offspring. Blood glucose and plasma insulin concentrations were measured before and during a glucose tolerance test. EFAD offspring fed STD were leaner with lower plasma leptin and insulin concentrations compared to controls. EFAD offspring fed HFD were resistant to diet-induced obesity, had higher energy expenditure and lower levels of plasma leptin and insulin compared to controls. These results indicate that the fatty acid composition during lactation is important for body composition and glucose tolerance in the adult offspring. |
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Authors:
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Vilborg Palsdottir; Anna Wickman; Niklas Andersson; Rahil Hezaveh; Bob Olsson; Britt G Gabrielsson; Birgitta Strandvik |
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Publication Detail:
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Type: Journal Article Date: 2010-12-21 |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 84 ISSN: 1532-2823 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2011 Mar-Apr |
Date Detail:
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Created Date: 2011-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
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Languages: eng Pagination: 85-92 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, 416 85 Gothenburg, Sweden; Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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