Document Detail


Postnatal changes of some enzymatic activities of energy supplying metabolism in the cortex, inner and outer medulla of the rat kidney.
MedLine Citation:
PMID:  6448414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. In rat kidney cortex, outer and inner medulla the development of activities of seven enzymes was investigated during postnatal ontogeny (10, 20, 30, 60 and 90 days of age). The enzymes were selected in such a manner, as to characterize most of the main metabolic pathways of energy supplying metabolism: hexokinase (glucose phosphorylation, HK), glycerol-3-phosphate dehydrogenase (glycerolphosphate metabolism or shunt, GPDH), triose phosphate dehydrogenase (glycolytic carbohydrate breakdown, TPDH), lactate dehydrogenase (lactate metabolism, LDH), citrate synthase (tricarboxylic acid cycle, aerobic metabolism, CS), malate NAD dehydrogenase (tricarboxylic acid cycle, intra-extra mitochondrial hydrogen transport, MDH) and 3-hydroxyacyl-CoA-dehydrogenase (fatty acid catabolism, HOADH). 2. The renal cortex already differs metabolically from the medullar structures on the 10th day of life. It displays a high activity of aerobic breakdown of both fatty acids and carbohydrates. Its metabolic capacity further increases up to the 30th day of life. 3. The outer medullar structure is not grossly different from the inner medulla on the 10th day of life. Further it differentiates into a highly aerobic tissue mainly able to utilize carbohydrates. It can, however, to some extent, also utilize fatty acids aerobically and produce lactate from carbohydrates anaerobically. 4. The inner medullar structure is best equipped to utilize carbohydrates by anaerobic glycolysis, forming lactate. This feature is already pronounced on the 10th day of life, its capacity increases to some extent during postnatal development, being highest between the 10th and the 60th day of life.
Authors:
J Nováková; K Capek; A Bass; J Teisinger; V Vítek; M Popp
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiologia Bohemoslovaca     Volume:  29     ISSN:  0369-9463     ISO Abbreviation:  Physiol Bohemoslov     Publication Date:  1980  
Date Detail:
Created Date:  1980-12-18     Completed Date:  1980-12-18     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0175317     Medline TA:  Physiol Bohemoslov     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  289-98     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
3-Hydroxyacyl CoA Dehydrogenases / metabolism
Age Factors
Animals
Citrate (si)-Synthase / metabolism
Energy Metabolism*
Female
Glyceraldehyde-3-Phosphate Dehydrogenases / metabolism
Glycerolphosphate Dehydrogenase / metabolism
Hexokinase / metabolism
Kidney / enzymology*
Kidney Cortex / enzymology
Kidney Medulla / enzymology
L-Lactate Dehydrogenase / metabolism
Malate Dehydrogenase / metabolism
Rats
Chemical
Reg. No./Substance:
EC 1.1.-/Glycerolphosphate Dehydrogenase; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 1.1.1.35/3-Hydroxyacyl CoA Dehydrogenases; EC 1.1.1.37/Malate Dehydrogenase; EC 1.2.1.-/Glyceraldehyde-3-Phosphate Dehydrogenases; EC 2.3.3.1/Citrate (si)-Synthase; EC 2.7.1.1/Hexokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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