| Postnatal changes in the role of NMDA in the isolated spinal cord of the hamster, Mesocricetus auratus. | |
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MedLine Citation:
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PMID: 7749588 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The frequency of spontaneous activity recorded from lumbar dorsal roots and the lumbar dorsal horn of isolated spinal cord preparations taken from hamsters aged between 2 days to 8 weeks showed an age dependent sensitivity to 1 mM Mg2+ and 5 microM AP5. Spontaneous dorsal root and dorsal horn activity in cords from animals less than 3 weeks of age was depressed by 1 mM Mg2+ and 5 microM AP5. Cords taken from animals older than 3 weeks showed significantly less depression of spontaneous activity. The application of 10 microM NMDA to the cord produced a small (33%) depression in spontaneous dorsal root and dorsal horn activity in cords from 4 to 6 week old animals. Cords from younger animals exhibited a complex response to NMDA, with an initial increase in spontaneous activity followed by a profound (77%) depression of the firing rate. These results indicate that there are substantial changes taking place in the pharmacology of the dorsal horn during the early weeks of life, and care must be exercised when extrapolating results obtained from neonatal preparations to adult animals. |
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Authors:
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R Abdul-Razzak; J Bagust; G A Kerkut |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Comparative biochemistry and physiology. Pharmacology, toxicology and endocrinology Volume: 107 ISSN: - ISO Abbreviation: Comp Biochem Physiol Pharmacol Toxicol Endocrinol Publication Date: 1994 Feb |
Date Detail:
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Created Date: 1995-06-16 Completed Date: 1995-06-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9430518 Medline TA: Comp Biochem Physiol Pharmacol Toxicol Endocrinol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 205-13 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, University of Southampton, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2-Amino-5-phosphonovalerate
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pharmacology Action Potentials / drug effects Aging / physiology Animals Cricetinae Magnesium / pharmacology, physiology Mesocricetus N-Methylaspartate / physiology* Spinal Cord / drug effects, growth & development*, physiology |
| Chemical | |
Reg. No./Substance:
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6384-92-5/N-Methylaspartate; 7439-95-4/Magnesium; 76726-92-6/2-Amino-5-phosphonovalerate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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