Document Detail

Postnatal changes in nerve growth factor and brain derived neurotrophic factor levels in the retina, visual cortex, and geniculate nucleus in rats with retinitis pigmentosa.
MedLine Citation:
PMID:  12809983     Owner:  NLM     Status:  MEDLINE    
Royal College of Surgeons (RCS) rats are a well established animal model of inherited retinitis pigmentosa (RP). Using RCS rats we examined the distribution of nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) in the visual cortex, geniculate nucleus and retina at three different postnatal ages. It was found that the retina of rats with RP expresses low amounts of NGF and BDNF in young and adult life. Altered levels of these factors were found in the visual cortex and in the geniculate nucleus. Our findings indicate that NGF and BDNF are differentially affected in the visual system of developing and adult RCS rats, suggesting that neurotrophins may be implicated in the pathogenesis of inherited RP.
Tiziana Amendola; Marco Fiore; Luigi Aloe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  345     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-17     Completed Date:  2003-07-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  37-40     Citation Subset:  IM    
Istituto di Neurobiologia e Medicina Molecolare, CNR Rome, viale Marx 15, Italy.
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MeSH Terms
Age Factors
Brain-Derived Neurotrophic Factor / metabolism*
Geniculate Bodies / growth & development,  metabolism*
Immunoenzyme Techniques
Nerve Growth Factor / metabolism*
Retina / growth & development,  metabolism*
Retinitis Pigmentosa / metabolism*
Reverse Transcriptase Polymerase Chain Reaction
Visual Cortex / growth & development,  metabolism*
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 9061-61-4/Nerve Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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