Document Detail

Postnatal changes in local cerebral blood flow measured by the quantitative autoradiographic [14C]iodoantipyrine technique in freely moving rats.
MedLine Citation:
PMID:  2777930     Owner:  NLM     Status:  MEDLINE    
The postnatal changes in local cerebral blood flow in freely moving rats were measured by means of the quantitative autoradiographic [14C]iodoantipyrine method. The animals were studied at 10, 14, 17, 21 and 35 days and at the adult stage. At 10 days after birth, rates of blood flow were very low and quite homogeneous in most cerebral structures except in a few posterior areas. From these relatively uniform levels, values of local cerebral blood flow rose notably to reach a peak at 17 days in all brain regions studied. Rates of blood flow decreased between 17 and 21 days after birth and then increased from weaning time to reach the known characteristic distribution of the adult rat. The postnatal evolution of local cerebral blood in the rat is in good agreement with previous studies in other species such as dog and humans that also show higher rates of cerebral blood flow and glucose utilization at immature stages. However, in the rat, local cerebral blood flow and local cerebral glucose utilization are not coupled over the whole postnatal period studied, since blood flow rates reach peak values at 17 days whereas glucose utilization remains still quite low at that stage. The high rate of cerebral blood flow in the 17-day-old rat may reflect the energetic and biosynthetic needs of the actively developing brain that are completed by the summation of glucose and ketone body utilization.
A Nehlig; A Pereira de Vasconcelos; S Boyet
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  9     ISSN:  0271-678X     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-10-19     Completed Date:  1989-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  579-88     Citation Subset:  IM    
INSERM U272, Nancy, France.
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MeSH Terms
Aging / physiology
Animals, Newborn / growth & development,  physiology*
Antipyrine / analogs & derivatives*,  diagnostic use
Autoradiography / methods*
Carbon Radioisotopes / diagnostic use
Cerebrovascular Circulation*
Motor Activity
Reg. No./Substance:
0/Carbon Radioisotopes; 129-81-7/iodoantipyrine; 60-80-0/Antipyrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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