Document Detail

Postnatal aniracetam treatment improves prenatal ethanol induced attenuation of AMPA receptor-mediated synaptic transmission.
MedLine Citation:
PMID:  17493826     Owner:  NLM     Status:  MEDLINE    
Aniracetam is a nootropic compound and an allosteric modulator of AMPA receptors (AMPARs) which mediate synaptic mechanisms of learning and memory. Here we analyzed impairments in AMPAR-mediated synaptic transmission caused by moderate prenatal ethanol exposure and investigated the effects of postnatal aniracetam treatment on these abnormalities. Pregnant Sprague-Dawley rats were gavaged with ethanol or isocaloric sucrose throughout pregnancy, and subsequently the offspring were treated with aniracetam on postnatal days (PND) 18 to 27. Hippocampal slices prepared from these pups on PND 28 to 34 were used for the whole-cell patch-clamp recordings of AMPAR-mediated spontaneous and miniature excitatory postsynaptic currents in CA1 pyramidal cells. Our results indicate that moderate ethanol exposure during pregnancy results in impaired hippocampal AMPAR-mediated neurotransmission, and critically timed aniracetam treatment can abrogate this deficiency. These results highlight the possibility that aniracetam treatment can restore synaptic transmission and ameliorate cognitive deficits associated with the fetal alcohol syndrome.
Nayana Wijayawardhane; Brian C Shonesy; Julia Vaglenova; Thirumalini Vaithianathan; Mark Carpenter; Charles R Breese; Alexander Dityatev; Vishnu Suppiramaniam
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-03-30
Journal Detail:
Title:  Neurobiology of disease     Volume:  26     ISSN:  0969-9961     ISO Abbreviation:  Neurobiol. Dis.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-22     Completed Date:  2007-08-24     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9500169     Medline TA:  Neurobiol Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  696-706     Citation Subset:  IM    
Department of Pharmacal Sciences, 401 Walker Building, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA.
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MeSH Terms
Alcohol-Induced Disorders, Nervous System / drug therapy*,  metabolism,  physiopathology
Animals, Newborn
Central Nervous System Depressants / adverse effects,  antagonists & inhibitors
Ethanol / adverse effects,  antagonists & inhibitors
Glutamic Acid / metabolism
Hippocampus / drug effects*,  metabolism,  physiopathology
Neural Pathways / drug effects,  metabolism,  physiopathology
Nootropic Agents / pharmacology,  therapeutic use
Organ Culture Techniques
Patch-Clamp Techniques
Prenatal Exposure Delayed Effects / drug therapy*,  metabolism,  physiopathology
Pyramidal Cells / drug effects,  metabolism
Pyrrolidinones / pharmacology*,  therapeutic use
Rats, Sprague-Dawley
Receptors, AMPA / drug effects*,  metabolism
Synaptic Transmission / drug effects*,  physiology
Treatment Outcome
Grant Support
Reg. No./Substance:
0/Central Nervous System Depressants; 0/Nootropic Agents; 0/Pyrrolidinones; 0/Receptors, AMPA; 56-86-0/Glutamic Acid; 64-17-5/Ethanol; 72432-10-1/aniracetam

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