| Postnatal aniracetam treatment improves prenatal ethanol induced attenuation of AMPA receptor-mediated synaptic transmission. | |
| | |
MedLine Citation:
|
PMID: 17493826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Aniracetam is a nootropic compound and an allosteric modulator of AMPA receptors (AMPARs) which mediate synaptic mechanisms of learning and memory. Here we analyzed impairments in AMPAR-mediated synaptic transmission caused by moderate prenatal ethanol exposure and investigated the effects of postnatal aniracetam treatment on these abnormalities. Pregnant Sprague-Dawley rats were gavaged with ethanol or isocaloric sucrose throughout pregnancy, and subsequently the offspring were treated with aniracetam on postnatal days (PND) 18 to 27. Hippocampal slices prepared from these pups on PND 28 to 34 were used for the whole-cell patch-clamp recordings of AMPAR-mediated spontaneous and miniature excitatory postsynaptic currents in CA1 pyramidal cells. Our results indicate that moderate ethanol exposure during pregnancy results in impaired hippocampal AMPAR-mediated neurotransmission, and critically timed aniracetam treatment can abrogate this deficiency. These results highlight the possibility that aniracetam treatment can restore synaptic transmission and ameliorate cognitive deficits associated with the fetal alcohol syndrome. |
| | |
Authors:
|
Nayana Wijayawardhane; Brian C Shonesy; Julia Vaglenova; Thirumalini Vaithianathan; Mark Carpenter; Charles R Breese; Alexander Dityatev; Vishnu Suppiramaniam |
Related Documents
:
|
8250896 - Formation of farnesal and 3-hydroxy-2,3-dihydrofarnesal from farnesol by protoplasts of... 16814936 - Prevalence of cocaine and marijuana use in the last trimester of adolescent pregnancy: ... 16562406 - Alcohol use by pregnant women: partners, knowledge, and other predictors. 9451756 - Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmenta... 8459956 - Immediate postpartum curettage: accelerated recovery from severe preeclampsia. 7848066 - Fetal weights and measurements as determined by postmortem examination and their correl... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-03-30 |
Journal Detail:
|
Title: Neurobiology of disease Volume: 26 ISSN: 0969-9961 ISO Abbreviation: Neurobiol. Dis. Publication Date: 2007 Jun |
Date Detail:
|
Created Date: 2007-05-22 Completed Date: 2007-08-24 Revised Date: 2007-12-03 |
Medline Journal Info:
|
Nlm Unique ID: 9500169 Medline TA: Neurobiol Dis Country: United States |
Other Details:
|
Languages: eng Pagination: 696-706 Citation Subset: IM |
Affiliation:
|
Department of Pharmacal Sciences, 401 Walker Building, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alcohol-Induced Disorders, Nervous System
/
drug therapy*,
metabolism,
physiopathology Animals Animals, Newborn Central Nervous System Depressants / adverse effects, antagonists & inhibitors Ethanol / adverse effects, antagonists & inhibitors Female Glutamic Acid / metabolism Hippocampus / drug effects*, metabolism, physiopathology Male Neural Pathways / drug effects, metabolism, physiopathology Nootropic Agents / pharmacology, therapeutic use Organ Culture Techniques Patch-Clamp Techniques Pregnancy Prenatal Exposure Delayed Effects / drug therapy*, metabolism, physiopathology Pyramidal Cells / drug effects, metabolism Pyrrolidinones / pharmacology*, therapeutic use Rats Rats, Sprague-Dawley Receptors, AMPA / drug effects*, metabolism Synaptic Transmission / drug effects*, physiology Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
|
AA11164/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Central Nervous System Depressants; 0/Nootropic Agents; 0/Pyrrolidinones; 0/Receptors, AMPA; 56-86-0/Glutamic Acid; 64-17-5/Ethanol; 72432-10-1/aniracetam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluation of corrosion behaviors and surface profiles of platinum-coated electrodes by electrochemi...
Next Document: Crosstalk between HIF-1 and ROCK pathways in neuronal differentiation of mesenchymal stem cells, neu...