| Postnatal weight gain modifies severity and functional outcome of oxygen-induced proliferative retinopathy. | |
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MedLine Citation:
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PMID: 21056995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In clinical studies, postnatal weight gain is strongly associated with retinopathy of prematurity (ROP). However, animal studies are needed to investigate the pathophysiological mechanisms of how postnatal weight gain affects the severity of ROP. In the present study, we identify nutritional supply as one potent parameter that affects the extent of retinopathy in mice with identical birth weights and the same genetic background. Wild-type pups with poor postnatal nutrition and poor weight gain (PWG) exhibit a remarkably prolonged phase of retinopathy compared to medium weight gain or extensive weight gain pups. A high (r(2) = 0.83) parabolic association between postnatal weight gain and oxygen-induced retinopathy severity is observed, as is a significantly prolonged phase of proliferative retinopathy in PWG pups (20 days) compared with extensive weight gain pups (6 days). The extended retinopathy is concomitant with prolonged overexpression of retinal vascular endothelial growth factor in PWG pups. Importantly, PWG pups show low serum levels of nonfasting glucose, insulin, and insulin-like growth factor-1 as well as high levels of ghrelin in the early postoxygen-induced retinopathy phase, a combination indicative of poor metabolic supply. These differences translate into visual deficits in adult PWG mice, as demonstrated by impaired bipolar and proximal neuronal function. Together, these results provide evidence for a pathophysiological correlation between poor postnatal nutritional supply, slow weight gain, prolonged retinal vascular endothelial growth factor overexpression, protracted retinopathy, and reduced final visual outcome. |
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Authors:
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Andreas Stahl; Jing Chen; Przemyslaw Sapieha; Molly R Seaward; Nathan M Krah; Roberta J Dennison; Tara Favazza; Felicitas Bucher; Chatarina Löfqvist; Huy Ong; Ann Hellström; Sylvain Chemtob; James D Akula; Lois E H Smith |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-11-05 |
Journal Detail:
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Title: The American journal of pathology Volume: 177 ISSN: 1525-2191 ISO Abbreviation: Am. J. Pathol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-01 Completed Date: 2011-03-15 Revised Date: 2012-04-30 |
Medline Journal Info:
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Nlm Unique ID: 0370502 Medline TA: Am J Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 2715-23 Citation Subset: AIM; IM |
Affiliation:
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Department of Ophthalmology, Harvard Medical School, Children’s Hospital Boston, Boston, Massachusetts 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Animals, Newborn Disease Models, Animal Humans Infant, Newborn Mice Mice, Inbred C57BL Oxygen / adverse effects* Oxygen Inhalation Therapy / adverse effects Parturition / physiology Prognosis Retina / metabolism Retinopathy of Prematurity / diagnosis*, etiology*, genetics, pathology Severity of Illness Index* Vascular Endothelial Growth Factor A / genetics, metabolism Weight Gain / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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EY017017/EY/NEI NIH HHS; EY017017-S1/EY/NEI NIH HHS; EY020308/EY/NEI NIH HHS; R01 EY017017/EY/NEI NIH HHS; //Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Vascular Endothelial Growth Factor A; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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