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Postnatal Developmental Changes in the Pituitary-Ovarian Axis in Preterm and Term Infant Girls.
MedLine Citation:
PMID:  21900380     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Context:Postnatal pituitary-testicular activation in infant boys is well characterized. However, the ovarian response to pituitary activation in infancy is less well understood.Objective:The aim of the study was to compare postnatal developmental changes in the pituitary-ovarian axis in preterm and term infant girls.Participants and Design:Sixty-three infant girls, divided into three groups according to gestational age (GA) [i.e. full term (FT; n = 29; GA, 37-42 wk), near term (NT; n = 17; GA, 34-37 wk), and preterm (PT; n = 17; GA, 24-34 wk)] were examined monthly from 1 wk (D7) to 6 months (M1-M6) of age and reexamined at the corrected age of 14 months (cM14).Main Outcome Measures:We performed a longitudinal follow-up of urinary FSH and serum anti-Müllerian hormone (AMH) levels and the number of follicles in transabdominal ovarian ultrasonography.Results:The postnatal FSH surge was stronger and more prolonged in NT and PT girls than in FT girls (P ≤ 0.001). Increased folliculogenesis and a rise in AMH levels were observed in all three groups after the FSH surge. In NT and PT girls, follicular development was delayed in comparison with FT girls, and a decrease in high FSH levels around the 40th postmenstrual week was temporally associated with the appearance of antral follicles in ultrasonography and an increase in AMH levels.Conclusions:The postnatal FSH surge results in transient ovarian stimulation in term and preterm girls. A delay in ovarian folliculogenesis shown in ovarian ultrasonography and by low serum AMH levels may provide an explanation for the exaggerated FSH surge in NT and PT girls.
Authors:
Tanja Kuiri-Hänninen; Sanna Kallio; Raija Seuri; Erja Tyrväinen; Annikki Liakka; Juha Tapanainen; Ulla Sankilampi; Leo Dunkel
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-7
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pediatrics (T.K.-H., U.S.), University of Eastern Finland and Kuopio University Hospital, FI-70211 Kuopio, Finland; Department of Obstetrics and Gynecology (S.K., J.T.), Clinical Research Center, Oulu University Hospital, FI-90014 Oulu, Finland; Department of Clinical Radiology (R.S., E.T.), Kuopio University Hospital, FI-70211 Kuopio, Finland; Department of Pathology (A.L.), Oulu University Hospital, FI-90014 Oulu, Finland; and William Harvey Research Institute (L.D.), Barts and the London, Queen Mary University of London, London EC1M 6BQ, United Kingdom.
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