Document Detail

Postnatal Decrease in Circulating Insulin-Like Growth Factor-I and Low Brain Volumes in Very Preterm Infants.
MedLine Citation:
PMID:  21289247     Owner:  NLM     Status:  Publisher    
Context: IGF-I and IGF binding protein-3 (IGFBP-3) are essential for growth and maturation of the developing brain. Objective: The aim of this study was to evaluate the association between postnatal serum concentrations of IGF-I and IGFBP-3 and brain volumes at term in very preterm infants. Design: Fifty-one infants with a mean (sd) gestational age (GA) of 26.4 (1.9) wk and birth weight (BW) of 888 (288) g were studied, with weekly blood sampling of IGF-I and IGFBP-3 from birth until 35 gestational weeks (GW) and daily calculation of protein and caloric intake. Magnetic resonance images obtained at 40 GW were segmented into total brain, cerebellar, cerebrospinal fluid, gray matter, and unmyelinated white matter volumes. Main Outcome Measures: We evaluated brain growth by measuring brain volumes using magnetic resonance imaging. Results: Mean IGF-I concentrations from birth to 35 GW correlated with total brain volume, unmyelinated white matter volume, gray matter volume, and cerebellar volume [r = 0.55 (P < 0.001); r = 0.55 (P < 0.001); r = 0.44 (P = 0.002); and r = 0.58 (P < 0.001), respectively]. Similar correlations were observed for IGFBP-3 concentrations. Correlations remained after adjustment for GA, mean protein and caloric intakes, gender, severe brain damage, and steroid treatment. Protein and caloric intakes were not related to brain volumes. Infants with BW small for GA had lower mean concentrations of IGF-I (P = 0.006) and smaller brain volumes (P = 0.001-0.013) than infants with BW appropriate for GA. Conclusion: Postnatal IGF-I and IGFBP-3 concentrations are positively associated with brain volumes at 40 GW in very preterm infants. Normalization of the IGF-I axis, directly or indirectly, may support normal brain development in very preterm infants.
Ingrid Hansen-Pupp; Holger Hövel; Ann Hellström; Lena Hellström-Westas; Chatarina Löfqvist; Elna-Marie Larsson; Francois Lazeyras; Vineta Fellman; Petra S Hüppi; David Ley
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-2
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Pediatrics (I.H.-P., H.H., V.F., D.L.), Department of Clinical Sciences Lund, Lund University, 221 85 Lund, Sweden; Department of Ophthalmology (A.H., C.L.), Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Gothenburg University, 405 30 Göteborg, Sweden; Departments of Women's and Children's Health (L.H.-W.), and Radiology (E.-M.L.), Uppsala University Hospital, 751 85 Uppsala, Sweden; Departments of Radiology-Center for Biomedical Imaging (F.L.) and Pediatrics (P.S.H.), Geneva University Hospital, 1211 Geneva, Switzerland; and Department of Pediatrics (V.F.), Clinical Sciences, University of Helsinki, 00014 Helsinki, Finland.
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