Document Detail

Postmortem whole-body CT angiography: evaluation of two contrast media solutions.
MedLine Citation:
PMID:  18430859     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of our study was to establish a standardized procedure for postmortem whole-body CT-based angiography with lipophilic and hydrophilic contrast media solutions and to compare the results of these two methods. MATERIALS AND METHODS: Minimally invasive postmortem CT angiography was performed on 10 human cadavers via access to the femoral blood vessels. Separate perfusion of the arterial and venous systems was established with a modified heart-lung machine using a mixture of an oily contrast medium and paraffin (five cases) and a mixture of a water-soluble contrast medium with polyethylene glycol (PEG) 200 in the other five cases. Imaging was executed with an MDCT scanner. RESULTS: The minimally invasive femoral approach to the vascular system provided a good depiction of lesions of the complete vascular system down to the level of the small supplying vessels. Because of the enhancement of well-vascularized tissues, angiography with the PEG-mixed contrast medium allowed the detection of tissue lesions and the depiction of vascular abnormalities such as pulmonary embolisms or ruptures of the vessel wall. CONCLUSION: The angiographic method with a water-soluble contrast medium and PEG as a contrast-agent dissolver showed a clearly superior quality due to the lack of extravasation through the gastrointestinal vascular bed and the enhancement of soft tissues (cerebral cortex, myocardium, and parenchymal abdominal organs). The diagnostic possibilities of these findings in cases of antemortem ischemia of these tissues are not yet fully understood.
Steffen Ross; Danny Spendlove; Stephan Bolliger; Andreas Christe; Lars Oesterhelweg; Silke Grabherr; Michael J Thali; Erich Gygax
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  190     ISSN:  1546-3141     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-23     Completed Date:  2008-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1380-9     Citation Subset:  AIM; IM    
Centre for Forensic Imaging and Virtopsy, Institute of Forensic Medicine, University of Bern, Buehlstrasse 20, CH-3012 Bern, Switzerland.
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MeSH Terms
Aged, 80 and over
Autopsy / methods*
Contrast Media*
Drug Carriers
Iodized Oil / diagnostic use*
Middle Aged
Polyethylene Glycols
Tomography, X-Ray Computed*
Triiodobenzoic Acids / diagnostic use*
Reg. No./Substance:
0/Contrast Media; 0/Drug Carriers; 0/Polyethylene Glycols; 0/Triiodobenzoic Acids; 8001-40-9/Iodized Oil; 89797-00-2/iopentol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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