Document Detail

Postmortem findings in term neonates.
MedLine Citation:
PMID:  15251146     Owner:  NLM     Status:  MEDLINE    
Neonatal deaths in infants born at term are relatively rare in the USA, occurring in 0.9/1000 live births. Congenital malformations, perinatal asphyxia, infections and inborn errors of metabolism are the leading causes. Chromosomal malformation syndromes, congenital heart disease, pulmonary hypoplasia and severe neural tube defects comprise the majority of lethal malformations. Several skeletal dysplasias are lethal in the newborn infant. Group B Streptococcus still plays a major role in neonatal mortality while deaths due to other infectious agents have decreased. Hypoxic ischaemic encephalopathy is a significant cause of neonatal death. Inborn errors of metabolism have variable presentations but some, such as the fatty acid oxidation disorders, may present in neonates and cause sudden death.
Halit Pinar
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in neonatology : SN     Volume:  9     ISSN:  1084-2756     ISO Abbreviation:  Semin Neonatol     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-14     Completed Date:  2004-10-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9606001     Medline TA:  Semin Neonatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  289-302     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Elsevier Ltd.
Department of Pathology and Laboratory Medicine, Division of Perinatal and Pediatric Pathology, Women and Infants Hospital, Brown Medical School, Providence, RI 02905, USA.
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MeSH Terms
Asphyxia Neonatorum / mortality,  pathology
Cause of Death
Chromosome Aberrations
Congenital Abnormalities / mortality,  pathology
Heart Defects, Congenital / mortality,  pathology
Infant, Newborn
Infant, Newborn, Diseases / mortality,  pathology*
Infection / mortality,  pathology
Meconium Aspiration Syndrome / mortality,  pathology
Metabolism, Inborn Errors / mortality,  pathology
Neural Tube Defects / mortality,  pathology
Pulmonary Valve Insufficiency / mortality,  pathology

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