Document Detail


Postmortem diagnosis of acute anaphylaxis by serum tryptase analysis. A case report.
MedLine Citation:
PMID:  8422006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Systemic anaphylaxis is an acute allergic emergency resulting from generalized mast cell degranulation. In the United States, it is estimated that anaphylaxis accounts for about 500 deaths each year. Hymenoptera-sting hypersensitivity is one of the most common causes of systemic anaphylaxis. The authors report a case of a healthy 26-year-old man who developed acute anaphylaxis after a bee sting, could not be resuscitated, and died within 1 hour. At autopsy, performed 14 hours after the event, the only pathologic findings were laryngeal edema and congestion of lung. Postmortem tryptase levels in the blood were obtained and were instrumental in confirming a diagnosis of acute anaphylaxis. This case is reported to discuss the difficulties associated with using traditional histamine levels in making a diagnosis of anaphylaxis and to validate the value of using tryptase levels to document acute anaphylaxis as a cause of death, even when serum is not obtained until many hours after death.
Authors:
M Q Ansari; J L Zamora; M F Lipscomb
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  99     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-02-12     Completed Date:  1993-02-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  101-3     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, University of Texas, Southwestern Medical Center, Dallas 75235.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anaphylaxis / diagnosis*
Chymases
Clinical Enzyme Tests*
Humans
Male
Serine Endopeptidases / blood*
Time Factors
Tryptases
Chemical
Reg. No./Substance:
EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.-/chymase 2; EC 3.4.21.39/Chymases; EC 3.4.21.59/Tryptases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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