Document Detail


Postmortem citalopram concentrations: alone or along with other compounds.
MedLine Citation:
PMID:  15317201     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Citalopram, an antidepressant whose use has become more widespread in Spain in recent years participates directly and indirectly in the lethal mechanism in voluntary and involuntary poisonings. There were 30 cases of autopsies in the Madrid region where citalopram and other psychoactive substances (psychotropic drugs, alcohol, opiates) were detected in the corpses. The postmortem citalopram levels in relation to the manner and mechanism of death were evaluated, and a significant difference between the toxic and nontoxic cases (p < 0.01) was found. We studied the citalopram blood levels alone and along with other psychoactive products, and these cases were then further divided into those where the compounds were at deadly levels and those which were not. We found a range of citalopram levels between 0.37 and 0.83 microg/mL in which some cases were associated with citalopram toxicity and others were not. Citalopram blood levels of less than 0.35 microg/mL did not lead to fatal poisoning when it was the sole substance detected.
Authors:
Luis J Segura; Begoña Bravo
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of forensic sciences     Volume:  49     ISSN:  0022-1198     ISO Abbreviation:  J. Forensic Sci.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-08-19     Completed Date:  2004-10-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375370     Medline TA:  J Forensic Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  814-9     Citation Subset:  IM    
Affiliation:
Toxicology Laboratory, Instituto Anatómico Forense of Madrid, Ciudad Universitaria, Madrid, Spain. lseguraa@meditex.es
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antidepressive Agents, Second-Generation / analysis*,  poisoning
Benzodiazepines / analysis
Cause of Death
Central Nervous System Depressants / blood
Chromatography, High Pressure Liquid
Citalopram / analysis*,  poisoning
Ethanol / blood
Female
Gas Chromatography-Mass Spectrometry
Gastrointestinal Contents / chemistry
Humans
Male
Middle Aged
Narcotics / analysis
Psychotropic Drugs / analysis
Chemical
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 0/Central Nervous System Depressants; 0/Narcotics; 0/Psychotropic Drugs; 12794-10-4/Benzodiazepines; 59729-33-8/Citalopram; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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