Document Detail


Postmortem changes in the levels of monoamine metabolites in human cerebrospinal fluid.
MedLine Citation:
PMID:  1689267     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four monoamine metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol (MHPG) and 5-hydroxyindoleacetic acid (5-HIAA), were determined in the cerebrospinal fluid (CSF) of cadavers, whose causes of death had been suicidal hanging (SH) or ischemic heart failure (IHF). The concentration of DOPAC increased in parallel with the increment of the postmortem interval (PMI) (r = 0.626), whereas the concentrations of HVA, MHPG and 5-HIAA did not. The correlation coefficient was further increased by considering each cause of death separately: i.e., SH, r = 0.761; IHF, r = 0.705. These findings suggest the possible usefulness of the DOPAC level in CSF for estimating PMI.
Authors:
T Endo; S Hara; F Kuriiwa; S Kano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Forensic science international     Volume:  44     ISSN:  0379-0738     ISO Abbreviation:  Forensic Sci. Int.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-03-26     Completed Date:  1990-03-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902034     Medline TA:  Forensic Sci Int     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  61-8     Citation Subset:  IM    
Affiliation:
Department of Forensic Medicine, Tokyo Medical College, Japan.
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MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / cerebrospinal fluid*
Adult
Aged
Aged, 80 and over
Asphyxia / cerebrospinal fluid
Cause of Death
Chromatography, High Pressure Liquid
Coronary Disease / cerebrospinal fluid
Female
Glycols / cerebrospinal fluid*
Homovanillic Acid / cerebrospinal fluid*
Humans
Hydroxyindoleacetic Acid / cerebrospinal fluid*
Male
Methoxyhydroxyphenylglycol / cerebrospinal fluid*
Middle Aged
Phenylacetates / cerebrospinal fluid*
Postmortem Changes*
Suicide
Chemical
Reg. No./Substance:
0/Glycols; 0/Phenylacetates; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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