| Postmortem blood cadmium, lead, and mercury concentrations: comparisons with regard to sampling location and reference ranges for living persons. | |
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MedLine Citation:
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PMID: 20406536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study's goal was to determine cadmium (Cd), lead (Pb), total mercury (THg), and inorganic mercury (IHg) levels in human cadavers to compare measured levels with established reference ranges for living persons and to determine whether blood levels varied with time from death to sample collection or by body collection site. Subjects (n = 66) recruited from the Fulton County Medical Examiner's Office in Atlanta, GA, were 20 years of age or older, had no penetrating trauma, no obvious source of environmental contamination of the vasculature, and had whole blood accessible from the femoral (F) site, the cardiac (C) site, or both. Geometric mean results were as follows: 2.59 microg/L F-Cd; 11.81 microg/L C-Cd; 1.03 microg/L F-THg; 2.01 microg/L C-THg; 0.29 microg/L F-IHg; 0.49 microg/L C-IHg; 1.78 microg/dL F-Pb; and 1.87 microg/dL C-Pb. Both F- and C-Cd levels as well as C-THg levels were significantly higher than reference values among living persons (C- and F-Cd, p < 0.0001 and C-THg, p = 0.0001, respectively). Based on regression modeling, as the postmortem interval increased, blood Cd levels increased (p < 0.006). Postmortem blood Cd concentrations were elevated compared to population values and varied with respect to sampling location and postmortem interval. |
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Authors:
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Joshua G Schier; Michael Heninger; Amy Wolkin; Stephanie Kieszak; Kathleen L Caldwell; Geroncio C Fajardo; Robert Jones; Carol Rubin; Randy Hanzlick; John D Osterloh; Michael A McGeehin |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of analytical toxicology Volume: 34 ISSN: 1945-2403 ISO Abbreviation: J Anal Toxicol Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-21 Completed Date: 2010-09-27 Revised Date: 2011-05-10 |
Medline Journal Info:
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Nlm Unique ID: 7705085 Medline TA: J Anal Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 129-34 Citation Subset: IM |
Affiliation:
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Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cadmium / blood* Female Femoral Artery / chemistry Heart Atria / chemistry Humans Lead / blood* Male Mass Spectrometry Mercury / blood* Middle Aged Postmortem Changes* Reference Values Spectrophotometry, Atomic Venae Cavae / chemistry Young Adult |
| Chemical | |
Reg. No./Substance:
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7439-92-1/Lead; 7439-97-6/Mercury; 7440-43-9/Cadmium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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