| Postmortem acidification of blood/organs induces an increase in flecainide concentration in cardiac blood and the contribution of the lungs to this increase. | |
| | |
MedLine Citation:
|
PMID: 20109299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Postmortem acidification of blood and the contribution of this phenomenon to increased flecainide concentrations in cardiac blood were evaluated in rabbits. Flecainide was administered intravenously, antemortem peripheral blood was collected 15 min after administration, then rabbits were sacrificed. Blood and organs were collected immediately or 24 h after death, or immediately or 24 h after performance of cardiac massage. Postmortem left/right cardiac blood and organs showed lower pH than antemortem blood, and flecainide concentrations in all postmortem blood samples were higher than those in antemortem blood. Increased flecainide concentrations in cardiac blood were enhanced by postmortem cardiac massage and postmortem interval. In perfusion experiments using rabbit lung and heart, even if the flecainide concentration in inflow was kept constant, outflow concentrations were 2- to 3-fold higher than in inflow when inflow pH changed from 7.4 to 5.5. In contrast, flecainide concentration in outflow decreased immediately and then remained low when pH of perfusate changed from 5.5 to 7.4. These results demonstrate that flecainide accumulates in the lungs before death, and this accumulated flecainide releases into blood following postmortem acidification of blood/organs. |
| | |
Authors:
|
Kei Yoshitome; Hideo Ishizu; Satoru Miyaishi |
Related Documents
:
|
2279859 - Evaluation of blood flow measurements with microspheres and rubidium--an experimental s... 7184699 - Regional reaction types of the resistance vessels. 1702169 - Instantaneous restoration of regional organ blood flow after severe hemorrhage: effect ... 7063919 - Hemodynamic improvement after peritoneovenous shunting in nephrogenic ascites. 7212079 - Regional blood flows in salt loading hypertension in the dog. 9164709 - Syncope. a neurologist's viewpoint. 12805399 - High serum leptin is associated with attenuated coronary vasoreactivity. 2673339 - The effect of intravascular transfusion for rhesus haemolytic disease on umbilical arte... 18343199 - Potential donor segregation to promote blood donation. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of analytical toxicology Volume: 34 ISSN: 1945-2403 ISO Abbreviation: J Anal Toxicol Publication Date: 2010 Jan-Feb |
Date Detail:
|
Created Date: 2010-01-29 Completed Date: 2010-03-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7705085 Medline TA: J Anal Toxicol Country: United States |
Other Details:
|
Languages: eng Pagination: 26-31 Citation Subset: IM |
Affiliation:
|
Department of Legal Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anti-Arrhythmia Agents / administration & dosage, blood*, pharmacokinetics Coronary Vessels Flecainide / administration & dosage, blood*, pharmacokinetics Forensic Toxicology / methods Heart Massage Hydrogen-Ion Concentration Injections, Intravenous Lung / metabolism* Perfusion Rabbits |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Arrhythmia Agents; 54143-55-4/Flecainide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Simultaneous liquid chromatography-mass spectrometry quantification of urinary opiates, cocaine, and...
Next Document: Urine Drug Testing of Chronic Pain Patients. II. Prevalence Patterns of Prescription Opiates and Met...