Document Detail

Postmenopausal virilization after spousal use of topical androgens.
MedLine Citation:
PMID:  17254577     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To increase awareness of the potential to cause virilization in postmenopausal woman secondary to a spouse's use of topical androgen. DESIGN: Case report. SETTING: University-affiliated teaching hospital. PATIENT(S): A 63-year-old postmenopausal woman with virilization. INTERVENTION(S): Removal of the source of androgen exposure. MAIN OUTCOME MEASURE(S): Regression of the biochemical and physical signs of androgen excess in a woman after cessation of T gel use by her partner, and reinitiation of use with precautions against potential methods of transfer. RESULT(S): This case highlights the unintentional transdermal absorption of testosterone sufficient to induce virilization in a couple who were aware of this potential problem. The apparent source of androgen absorption was a washcloth that the couple shared. The diagnosis can be established with a detailed history and a few blood tests (total and free T, and DHEAS) to exclude other sources of androgens. CONCLUSION(S): This report reinforces the need to consider exogenous androgen exposure in the differential diagnosis of virilization in adults when the more common causes have been excluded.
Zaher O Merhi; Nanette Santoro
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-01-24
Journal Detail:
Title:  Fertility and sterility     Volume:  87     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-13     Completed Date:  2007-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  976.e13-5     Citation Subset:  IM    
Maimonides Medical Center, Brooklyn, New York 11219, USA.
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MeSH Terms
Administration, Topical
Androgens / administration & dosage,  adverse effects*
Middle Aged
Skin Absorption
Virilism / etiology*
Reg. No./Substance:

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