Document Detail

Postmenopausal oral estrogen therapy and blood pressure in normotensive and hypertensive subjects: the Estrogen in the Prevention of Atherosclerosis Trial.
MedLine Citation:
PMID:  16278616     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine if 17beta-estradiol increases blood pressure in postmenopausal women. DESIGN: A total of 222 healthy postmenopausal women were randomly assigned to either 1 mg micronized 17beta-estradiol daily or placebo for 2 years. Blood pressure measurements were obtained every other month and common carotid artery intima-media thickness measured every 6 months. Statistical analyses comparing longitudinal changes in systolic and diastolic blood pressure between treatment groups used a mixed general linear model including interaction terms to evaluate variations by age or estradiol level. RESULTS: Both placebo and estradiol groups showed small declines in systolic and diastolic blood pressure during the trial among the normotensive subjects and subjects on antihypertensive medications. However, the decline did not differ significantly between the groups. Treatment effects on systolic blood pressure differed significantly by the age of the subject (interaction P value = 0.04) with younger women on estradiol showing on average a rise in systolic blood pressure, and older women a decline. The association between serum estradiol level and systolic blood pressure showed a similar modification with age (P = 0.03). Changes in systolic blood pressure in women on estradiol were positively correlated with intima-media thickness progression (P = 0.03). CONCLUSIONS: Overall, 17beta-estradiol did not influence changes in blood pressure in normotensive or hypertensive women. The effect of 17beta-estradiol treatment on systolic blood pressure may be influenced by a woman's age. Estradiol may increase systolic blood pressure in younger postmenopausal women, while having the opposite effect in older postmenopausal women.
Anne Z Steiner; Howard N Hodis; Rogerio A Lobo; Donna Shoupe; Min Xiang; Wendy J Mack
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2005-11-08
Journal Detail:
Title:  Menopause (New York, N.Y.)     Volume:  12     ISSN:  1072-3714     ISO Abbreviation:  Menopause     Publication Date:    2005 Nov-Dec
Date Detail:
Created Date:  2005-11-15     Completed Date:  2007-02-05     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9433353     Medline TA:  Menopause     Country:  United States    
Other Details:
Languages:  eng     Pagination:  728-33     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Southern California/Keck School of Medicine, Los Angeles, CA 90033, USA.
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MeSH Terms
Age Factors
Aged, 80 and over
Arteriosclerosis / prevention & control
Blood Pressure / drug effects*
Body Mass Index
Cohort Studies
Double-Blind Method
Estradiol / administration & dosage,  pharmacology*
Estrogen Replacement Therapy / methods*
Hypertension / drug therapy,  physiopathology*
Middle Aged
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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