| Postmenopausal hormones and incontinence: the Heart and Estrogen/Progestin Replacement Study. | |
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MedLine Citation:
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PMID: 11152919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether postmenopausal hormone therapy improves the severity of urinary incontinence. METHODS: We included measures of incontinence and voiding frequency in the Heart and Estrogen/Progestin Replacement Study, a randomized, blinded trial of the effect of hormone therapy among 2763 postmenopausal women younger than 80 years with coronary disease and intact uteri. This report includes 1525 participants who reported at least one episode of incontinence per week at baseline. Participants were randomly assigned to 0.625 mg of conjugated estrogens plus 2.5 mg of medroxyprogesterone acetate in one tablet daily (n = 768) or placebo (n = 757) and were followed for a mean of 4.1 years. Severity of incontinence was classified as improved (decrease of at least two episodes per week), unchanged (change of at most one episode per week), or worsened (increase of at least two episodes per week). RESULTS: Incontinence improved in 26% of the women assigned to placebo compared with 21% assigned to hormones, while 27% of the placebo group worsened compared with 39% of the hormone group (P =.001). This difference was evident by 4 months of treatment and was observed for both urge and stress incontinence. The number of incontinent episodes per week increased an average of 0.7 in the hormone group and decreased by 0.1 in the placebo group (P <.001). CONCLUSION: Daily oral estrogen plus progestin therapy was associated with worsening urinary incontinence in older postmenopausal women with weekly incontinence. We do not recommend this therapy for the treatment of incontinence. |
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Authors:
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D Grady; J S Brown; E Vittinghoff; W Applegate; E Varner; T Snyder; |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 97 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-01-26 Completed Date: 2001-02-22 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 116-20 Citation Subset: AIM; IM |
Affiliation:
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University of California, San Francisco, San Francisco, California 94105, USA. dgrady@itsa.ucsf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Drug Combinations Estrogen Replacement Therapy* Estrogens, Conjugated (USP) / pharmacology* Female Humans Medroxyprogesterone Acetate / pharmacology* Middle Aged Postmenopause / drug effects, physiology* Randomized Controlled Trials as Topic Treatment Failure Urinary Incontinence / drug therapy*, prevention & control Urinary Incontinence, Stress / drug therapy*, prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Estrogens, Conjugated (USP); 71-58-9/Medroxyprogesterone Acetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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