| Postmenopausal hypertension: role of the Renin-Angiotensin system. | |
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MedLine Citation:
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PMID: 20679182 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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After menopause, blood pressure increases in women. However, the underlying mechanisms responsible for postmenopausal hypertension are not completely understood. This study was conducted to determine the role that the renin-angiotensin system (RAS) plays in post-menopausal hypertension. Post-estrous cycling (postmenopausal) spontaneously hypertensive rats or young female controls were treated with losartan, an angiotensin (Ang) II type 1 receptor blocker, for 25 days. Mean arterial pressure was recorded continuously by radiotelemetry. Losartan significantly decreased blood pressure in postmenopausal rats and young female controls but failed to normalize blood pressure in postmenopausal rats to levels found in young controls. Plasma renin activity and plasma angiotensinogen were significantly elevated, and intrarenal Ang II type 1 receptor and renin mRNA expression were significantly downregulated in postmenopausal rats. Therefore, RAS only partially contributes to hypertension in postcycling spontaneously hypertensive rats, whereas hypertension in young females is mediated mainly by the RAS. The data suggest that other mechanisms besides activation of the RAS are likely involved in postmenopausal hypertension. |
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Authors:
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Licy L Yanes; Damian G Romero; Radu Iliescu; Huimin Zhang; Deborah Davis; Jane F Reckelhoff |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-08-02 |
Journal Detail:
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Title: Hypertension Volume: 56 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-19 Completed Date: 2010-09-13 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 359-63 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State Street, Jackson, MS 39216-4505, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Angiotensin II Type 1 Receptor Blockers / pharmacology Angiotensinogen / genetics, metabolism Animals Blood Pressure / drug effects Female Hypertension / genetics, metabolism, physiopathology* Kidney / drug effects, metabolism, physiopathology Losartan / pharmacology* Peptidyl-Dipeptidase A / genetics, metabolism Rats Rats, Inbred SHR Renin / genetics, metabolism Renin-Angiotensin System / drug effects, physiology* Reverse Transcriptase Polymerase Chain Reaction Telemetry |
| Grant Support | |
ID/Acronym/Agency:
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HL51971/HL/NHLBI NIH HHS; HL66072/HL/NHLBI NIH HHS; HL69194/HL/NHLBI NIH HHS; P01 HL051971-165260/HL/NHLBI NIH HHS; R01 HL066072-07/HL/NHLBI NIH HHS; R01 HL069194-07W1/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 11002-13-4/Angiotensinogen; 114798-26-4/Losartan; EC 3.4.15.1/Peptidyl-Dipeptidase A; EC 3.4.23.15/Renin |
| Comments/Corrections | |
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