Document Detail


Postmaturity in a genetic subtype of schizophrenia.
MedLine Citation:
PMID:  12956826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether postmaturity (gestation > 41 weeks), small for gestational age (SGA), and other pregnancy and birth complications that may elevate risk for neurodevelopmental disorders, are associated with elevated risk for schizophrenia in 22q11 Deletion Syndrome (22qDS), a genetic subtype of schizophrenia.
METHOD: Antepartum and intrapartum features were examined in 20 adults with 22qDS-schizophrenia and three comparison groups: newborn encephalopathy (n = 164) and healthy newborn controls (n = 400) from Badawi et al.'s (Br Med J 1998, 317: 1549) study, and 16 non-psychotic 22qDS adults (22qDS-NP).
RESULTS: Postmaturity (OR 13.0, 95% CI 3.95, 42.77; P < 0.001) and SGA (OR 3.59, 95% CI 1.23, 10.5; P = 0.03) were more prevalent in 22qDS-SZ than controls. Postmaturity was non-significantly more prevalent in 22qDS-SZ than in newborn encephalopathy (P = 0.06) or 22qDS-NP (P = 0.2). SGA showed similar rates in the two 22qDS groups and newborn encephalopathy, but was more prevalent in 22qDS-NP than controls (P = 0.05).
CONCLUSION: The results suggest that postmaturity may be associated with expression of schizophrenia in a 22qDS subtype of schizophrenia. SGA may be a non-specific marker of neurodevelopmental disturbance.
Authors:
E W C Chow; J Husted; R Weksberg; A S Bassett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta psychiatrica Scandinavica     Volume:  108     ISSN:  0001-690X     ISO Abbreviation:  Acta Psychiatr Scand     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-05     Completed Date:  2004-01-20     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0370364     Medline TA:  Acta Psychiatr Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  260-8     Citation Subset:  IM    
Affiliation:
Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Weight
Brain Diseases
Case-Control Studies
Chromosome Deletion*
Chromosomes, Human, Pair 22 / genetics*
Female
Humans
Infant, Newborn
Infant, Postmature*
Male
Risk Factors
Schizophrenia / genetics*,  physiopathology*
Grant Support
ID/Acronym/Agency:
97800//Canadian Institutes of Health Research
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