| Postmaturity in a genetic subtype of schizophrenia. | |
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MedLine Citation:
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PMID: 12956826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine whether postmaturity (gestation > 41 weeks), small for gestational age (SGA), and other pregnancy and birth complications that may elevate risk for neurodevelopmental disorders, are associated with elevated risk for schizophrenia in 22q11 Deletion Syndrome (22qDS), a genetic subtype of schizophrenia. METHOD: Antepartum and intrapartum features were examined in 20 adults with 22qDS-schizophrenia and three comparison groups: newborn encephalopathy (n = 164) and healthy newborn controls (n = 400) from Badawi et al.'s (Br Med J 1998, 317: 1549) study, and 16 non-psychotic 22qDS adults (22qDS-NP). RESULTS: Postmaturity (OR 13.0, 95% CI 3.95, 42.77; P < 0.001) and SGA (OR 3.59, 95% CI 1.23, 10.5; P = 0.03) were more prevalent in 22qDS-SZ than controls. Postmaturity was non-significantly more prevalent in 22qDS-SZ than in newborn encephalopathy (P = 0.06) or 22qDS-NP (P = 0.2). SGA showed similar rates in the two 22qDS groups and newborn encephalopathy, but was more prevalent in 22qDS-NP than controls (P = 0.05). CONCLUSION: The results suggest that postmaturity may be associated with expression of schizophrenia in a 22qDS subtype of schizophrenia. SGA may be a non-specific marker of neurodevelopmental disturbance. |
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Authors:
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E W C Chow; J Husted; R Weksberg; A S Bassett |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta psychiatrica Scandinavica Volume: 108 ISSN: 0001-690X ISO Abbreviation: Acta Psychiatr Scand Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-09-05 Completed Date: 2004-01-20 Revised Date: 2011-08-25 |
Medline Journal Info:
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Nlm Unique ID: 0370364 Medline TA: Acta Psychiatr Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 260-8 Citation Subset: IM |
Affiliation:
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Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Birth Weight Brain Diseases Case-Control Studies Chromosome Deletion* Chromosomes, Human, Pair 22 / genetics* Female Humans Infant, Newborn Infant, Postmature* Male Risk Factors Schizophrenia / genetics*, physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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97800//Canadian Institutes of Health Research |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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