Document Detail

Postmarketing surveillance of food additives.
MedLine Citation:
PMID:  7838988     Owner:  NLM     Status:  MEDLINE    
Postmarketing surveillance of consumption and of anecdotal reports of adverse health effects has been recognized by a number of regulatory authorities as a potentially useful method to provide further assurance of the safety of new food additives. Surveillance of consumption is used to estimate more reliably actual consumption levels relative to the acceptable daily intake of a food additive. Surveillance of anecdotal reports of adverse health effects is used to determine the presence of infrequent idiosyncratic responses that may not be predictable from premarket evaluations. The high-intensity sweetner, aspartame, is a food additive that has been the subject of extensive evaluation during the postmarketing period and is thus used as an example to discuss postmarketing surveillance.
H H Butchko; C Tschanz; F N Kotsonis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Regulatory toxicology and pharmacology : RTP     Volume:  20     ISSN:  0273-2300     ISO Abbreviation:  Regul. Toxicol. Pharmacol.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-03-02     Completed Date:  1995-03-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8214983     Medline TA:  Regul Toxicol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  105-18     Citation Subset:  IM    
Preclinical and Clinical Research, NutraSweet Company, Deerfield, Illinois 60015.
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MeSH Terms
Aspartame / adverse effects
Food Additives / adverse effects*
Legislation, Food*
Product Surveillance, Postmarketing / trends*
United States
Reg. No./Substance:
0/Food Additives; 22839-47-0/Aspartame

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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