Document Detail

Postischemic recovery rate of cerebral ATP, phosphocreatine, pH, and evoked potentials.
MedLine Citation:
PMID:  2513729     Owner:  NLM     Status:  MEDLINE    
We tested the hypotheses that after complete cerebral ischemia, first, rate of recovery of ATP, phosphocreatine (PCr), and intracellular pH (pHi) varies with ischemic duration and second, rate of metabolic recovery is a more sensitive predictor of consequent electrophysiological deficit than steady-state metabolic recovery. With the use of transient intracranial hypertension in anesthetized dogs, ischemic duration was set for either 3, 12, or 30 min, which depressed somatosensory-evoked potential (SEP) recovery amplitude by 30, 59, and 88%, respectively. In contrast, ATP, PCr, and pHi, measured by 31P magnetic resonance spectroscopy, fully recovered. When ischemic duration was increased from 3 to 12 min, mean recovery time of ATP (6 min) remained rapid but that of pHi (12-28 min) was prolonged. After 30 min of ischemia, pHi recovery was not slowed further (25 min) but that of ATP was now markedly prolonged (36 min). PCr recovery time increased progressively with ischemic duration (5, 11, and 21 min, respectively) and correlated best with SEP recovery (r = 0.74). We conclude that the brain's ability to rapidly normalize pH is a sensitive predictor of electrophysiological recovery after short ischemia but that ATP regeneration becomes important with prolonged ischemia. PCr recovery rate was the best overall predictor, probably because it depends on both pHi and the ratio of ATP to ADP by the creatine kinase reaction.
M K Nishijima; R C Koehler; P D Hurn; S M Eleff; S Norris; W E Jacobus; R J Traystman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  257     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-02-02     Completed Date:  1990-02-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1860-70     Citation Subset:  IM    
Department of Anesthesiology/Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.
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MeSH Terms
Adenosine Triphosphate / metabolism*
Carbon Dioxide / blood
Cerebrovascular Circulation*
Evoked Potentials
Hemoglobins / analysis
Hydrogen-Ion Concentration
Ischemic Attack, Transient / metabolism,  physiopathology*
Magnetic Resonance Spectroscopy / methods
Oxygen / blood
Partial Pressure
Phosphates / metabolism
Phosphocreatine / metabolism*
Grant Support
Reg. No./Substance:
0/Hemoglobins; 0/Phosphates; 124-38-9/Carbon Dioxide; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine; 7782-44-7/Oxygen

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