| Postischemic infusion of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, protects against myocardial stunning in swine. | |
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MedLine Citation:
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PMID: 20464430 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: It seems controversial whether or not neutrophil elastase inhibitors are effective in attenuating myocardial ischemia/reperfusion injury. We thus investigated possible protective effects of sivelestat, a neutrophil elastase inhibitor, against myocardial stunning i.e., prolonged myocardial dysfunction following a brief episode of ischemia. METHODS: Swine were divided into control group (group C), low-dose sivelestat group (group L), and high-dose sivelestat group (group H) (n = 7 for each group). All the swine were subjected to myocardial ischemia through ligation of the left anterior descending (LAD) coronary artery for 12-min, followed by 90-min reperfusion. Sivelestat was infused intracoronally at concentrations of 6 and 60 mg/ml throughout the reperfusion period in groups L and H, respectively, while saline was infused in the group C. Heart rate (HR), left ventricular developed pressure (LVdP), maximum rate of LVdP (LVdP/dt (max)), LV end-diastolic pressure (LVEDP), percentage of segment shortening (%SS, an index of regional myocardial contractility), and coronary venous interleukin-6 concentration in the LAD perfusion area were measured before ischemic induction and during reperfusion. RESULTS: The ischemia/reperfusion insult did not cause any significant changes in HR, LVdP, LVdP/dt (max), and LVEDP in all groups. However, it significantly reduced %SS in the LAD perfusion area and increased the interleukin-6 concentration in group C. Those changes in %SS and the interleukin-6 concentration were both greatly attenuated, but not prevented, in groups L and H. CONCLUSION: Sivelestat presumably attenuates myocardial contractile dysfunction due to myocardial stunning by inhibiting neutrophil-derived elastase, thereby suppressing the production of interleukin-6 in activated neutrophils. |
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Authors:
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Daiji Akiyama; Tetsuya Hara; Osamu Yoshitomi; Takuji Maekawa; Sungsam Cho; Koji Sumikawa |
Publication Detail:
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Type: Journal Article Date: 2010-05-13 |
Journal Detail:
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Title: Journal of anesthesia Volume: 24 ISSN: 1438-8359 ISO Abbreviation: J Anesth Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-05 Completed Date: 2010-12-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8905667 Medline TA: J Anesth Country: Japan |
Other Details:
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Languages: eng Pagination: 575-81 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Circulation / drug effects Female Glycine / analogs & derivatives*, therapeutic use Interleukin-6 / biosynthesis Male Myocardial Ischemia / drug therapy* Myocardial Stunning / prevention & control* Proteinase Inhibitory Proteins, Secretory / therapeutic use* Sulfonamides / therapeutic use* Swine |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Proteinase Inhibitory Proteins, Secretory; 0/Sulfonamides; 127373-66-4/ONO 5046; 56-40-6/Glycine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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