Document Detail


Postischemic hypervascularity of infancy: a stage in the evolution of ischemic brain damage with characteristic CT scan.
MedLine Citation:
PMID:  6164337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One to 2 weeks after severe brain ischemia, four infants developed an unusual vascular lesion with a characteristic appearance on computed tomography that has not been reported previously. Restricted areas (most frequently the basal ganglia and thalamus) displayed increased attenuation, which enhanced further upon infusion of contrast medium. Autopsy of one infant revealed that the CT abnormality corresponded to an extremely dense neovascular network which had almost completely replaced the parenchyma in that region. We postulate that this pathological change is a stage in the organization of ischemic brain damage reflecting the infant's vascular plasticity. Thus, hypoxia induces marked capillary proliferation in regions of normally high metabolism and capillary density. The CT pattern may prove useful in predicting the location and extent of sequelae to perinatal asphyxia.
Authors:
D A Shewmon; M Fine; J C Masdeu; E Palacios
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of neurology     Volume:  9     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-06-25     Completed Date:  1981-06-25     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  358-65     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Asphyxia Neonatorum / radiography
Brain / pathology
Brain Damage, Chronic / radiography*
Brain Ischemia / pathology,  radiography*
Cerebrovascular Circulation*
Female
Fetal Hypoxia / radiography
Humans
Hydrocephalus / radiography
Hypoxia, Brain / radiography
Infant
Infant, Newborn
Male
Neovascularization, Pathologic*
Pregnancy
Tomography, X-Ray Computed*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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