Document Detail

Postischemic exercise decreases neurogenesis in the adult rat dentate gyrus.
MedLine Citation:
PMID:  17018248     Owner:  NLM     Status:  MEDLINE    
Running exercise enhances neurogenesis in the normal adult and aged hippocampus. However, the effect of exercise on neurogenesis in the ischemic hippocampus is unclear. Here, we show that running exercise has different effects on ischemic and non-ischemic brain. Young (3-4-month-old) normotensive Wistar rats were used for this study. We administered bromodeoxyuridine (BrdU) to rats 7 days after the induction of transient forebrain ischemia or sham operation. BrdU-labeled cells were increased in the ischemic subgranular zone (SGZ) and granule cell layer (GCL) and double immunofluoresence showed approximately 80% of BrdU-labeled cells expressed neuronal markers. To assess the effect of running exercise on neurogenesis, BrdU-labeled cells in these regions were quantified after 1 day and 14 days. In sham-operated rats, the numbers of BrdU-labeled cells were significantly increased (2.2-fold) in the SGZ and GCL in response to running exercise. The numbers of BrdU-labeled cells were increased in response to ischemia, however, they were decreased 14 days after BrdU administration and running exercise accelerated the reduction in BrdU-labeled cells in ischemic rats. These findings suggest that running exercise has a negative effect on neurogenesis in the ischemic hippocampus. This may be important with respect to assessment of therapeutic approaches for functional recovery after stroke.
Yoshiki Yagita; Kazuo Kitagawa; Tsutomu Sasaki; Yasukazu Terasaki; Kenichi Todo; Emi Omura-Matsuoka; Masayasu Matsumoto; Masatsugu Hori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-02
Journal Detail:
Title:  Neuroscience letters     Volume:  409     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-24     Completed Date:  2007-01-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  24-9     Citation Subset:  IM    
Stroke Division, Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
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MeSH Terms
Antimetabolites / diagnostic use
Bromodeoxyuridine / diagnostic use
Cell Proliferation
Cell Survival / physiology
Dentate Gyrus / pathology*
Ischemic Attack, Transient / pathology*
Nerve Regeneration / physiology*
Neurons / pathology*,  physiology*
Physical Exertion / physiology*
Rats, Wistar
Running / physiology
Stem Cells / physiology
Reg. No./Substance:
0/Antimetabolites; 59-14-3/Bromodeoxyuridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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