Document Detail

Postischemic deterioration of sarcoplasmic reticulum: warm versus cold blood cardioplegia.
MedLine Citation:
PMID:  8239814     Owner:  NLM     Status:  MEDLINE    
Impaired cardiac sarcoplasmic reticulum (SR) function, as evidenced by reduced SR Ca2+ uptake rate and decreased SR Ca(2+)-adenosine triphosphatase activity, has been found in postischemic "stunned" myocardium and in hearts subjected to hypothermic arrest. In this study, we compared the effects of retrograde continuous coronary sinus warm blood cardioplegia (WBC) and retrograde intermittent cold blood cardioplegia (CBC) on cardiac SR function and postischemic ventricular functional recovery in pig hearts. Twelve in situ isolated pig hearts supported by cardiopulmonary bypass were subjected to 120 minutes of cardioplegic arrest with either WBC (37 degrees C) or CBC (6 degrees to 10 degrees C), followed by 60 minutes of 37 degrees C reperfusion. Left ventricular global contractile function and coronary blood flow were measured before arrest and during reperfusion. Cardiac SR was isolated from left ventricular biopsy specimens, and 45Ca2+ uptake by SR and SR Ca(2+)-adenosine triphosphatase activity were determined. The recovery of left ventricular global contractile function as indicated by the maximum of the first derivative of left ventricular pressure was significantly improved in the WBC group compared with that of the CBC group (70% versus 46%; p < 0.05). The SR Ca(2+)-adenosine triphosphatase activity was better preserved after 60 minutes reperfusion in WBC compared with CBC (0.31 +/- 0.02 versus 0.20 +/- 0.03 microM Pi/min/mg protein, p < 0.05), and the recovery of SR Ca2+ uptake was significantly improved by WBC compared with CBC (1.15 +/- 0.12 versus 0.83 +/- 0.04 microM Ca2+/min/mg protein; p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
X Liu; R M Engelman; Z Wei; N Maulik; J A Rousou; J E Flack; D W Deaton; D K Das
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  56     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1993-12-13     Completed Date:  1993-12-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1154-9     Citation Subset:  AIM; IM    
Department of Surgery, University of Connecticut School of Medicine, Farmington.
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MeSH Terms
Blood Flow Velocity / drug effects,  physiology
Calcium / pharmacokinetics
Calcium-Transporting ATPases / metabolism
Cardioplegic Solutions
Coronary Circulation / drug effects,  physiology
Creatine Kinase / blood
Heart Arrest, Induced
Myocardial Contraction / drug effects,  physiology
Myocardial Ischemia / metabolism,  physiopathology*,  surgery
Sarcoplasmic Reticulum / metabolism,  physiology*
Ventricular Function, Left / drug effects,  physiology
Grant Support
Reg. No./Substance:
0/Cardioplegic Solutions; 7440-70-2/Calcium; EC Kinase; EC ATPases
Comment In:
Ann Thorac Surg. 1993 Nov;56(5):1007-10   [PMID:  8239790 ]

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