| Postischemic [Ca2+] repletion improves cardiac performance without altering oxygen demands. | |
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MedLine Citation:
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PMID: 2369187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The positive inotropism expected with correction of postischemic hypocalcemia might be counterbalanced by potential aggravation of reperfusion injury, in particular by calcium overload. We evaluated the effect of normalizing blood calcium concentration ([Ca2+]) on postischemic left ventricular systolic and diastolic mechanics using oxygen consumption and indices derived from pressure-diameter relations. In 10 open-chest dogs on cardiopulmonary bypass, the hearts underwent 30 minutes of normothermic global ischemia followed by one hour of multidose hypothermic (4 degrees C), hypocalcemic (0.3 mmol/L) blood cardioplegia. After reperfusion, systemic [Ca2+] had decreased to 70% of control (p = 0.017). The left ventricular inotropic state was significantly depressed from baseline (control) values, but was restored to baseline levels by resumption of normocalcemia after one hour of reperfusion. Chamber stiffness increased by 308% (p = 0.006) after hypocalcemic reperfusion but decreased significantly after [Ca2+] correction. Recovery of left ventricular performance with [Ca2+] correction did not augment myocardial oxygen consumption from the postischemic uncorrected state (5.0 +/- 0.3 mL O2/min/100 g versus 5.3 +/- 0.3 mL O2/min/100 g). We conclude that normalizing [Ca2+] after blood cardioplegia improves postischemic left ventricular performance without adversely affecting compliance or oxygen consumption. |
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Authors:
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H Yokoyama; J S Julian; J Vinten-Johansen; W E Johnston; T D Smith; D S McGee; A R Cordell |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 49 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1990 Jun |
Date Detail:
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Created Date: 1990-08-13 Completed Date: 1990-08-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 894-902 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiothoracic Surgery, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects, physiology Calcium / blood* Calcium Chloride / administration & dosage, therapeutic use* Cardiac Output / drug effects, physiology Coronary Circulation / drug effects, physiology Dogs Heart / physiology* Heart Arrest, Induced Hypocalcemia / physiopathology Myocardial Contraction / drug effects*, physiology Myocardial Reperfusion Myocardium / metabolism* Oxygen Consumption / drug effects*, physiology Stroke Volume / drug effects, physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL36377/HL/NHLBI NIH HHS; HL40395/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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10043-52-4/Calcium Chloride; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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