| Postinfective diarrhoea and bile acid malabsorption. | |
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MedLine Citation:
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PMID: 9044199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postinfective irritable bowel syndrome with diarrhoea and idiopathic bile acid malabsorption remains an enigma. We examined the records of 84 patients whose 75SeHCAT scans were indicative of bile acid malabsorption (< 15% one week retention). Identifiable causes of bile acid malabsorption were: previous ileal surgery (7), Crohn's disease (22), radiation enteritis (13), vagotomy, gastrectomy or cholecystectomy (10) and miscellaneous (3). Sixteen of 29 patients with apparently idiopathic bile acid malabsorption gave a clear history of acute gastroenteritis before the onset of chronic diarrhoea lasting from 0.25-18 years until their positive 75SeHCAT scan. Only four cases of campylobacter, and one each of shigella and salmonella were documented. Extensive investigation failed to detect other possible pathologies. In response to bile acid sequestrants, mean stool frequency fell from 7.2 per day to 2.1 per day (p < 0.001). We have observed that postinfective chronic diarrhoea is associated with chronic bile acid malabsorption, which can be successfully treated with bile acid sequestrants such as cholestyramine. |
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Authors:
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S K Niaz; K Sandrasegaran; F H Renny; B J Jones |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the Royal College of Physicians of London Volume: 31 ISSN: 0035-8819 ISO Abbreviation: J R Coll Physicians Lond Publication Date: 1997 Jan-Feb |
Date Detail:
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Created Date: 1997-05-14 Completed Date: 1997-05-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7503108 Medline TA: J R Coll Physicians Lond Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 53-6 Citation Subset: IM |
Affiliation:
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Russells Hall Hospital, Dudley. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bile Acids and Salts / metabolism* Campylobacter Infections / complications Colonic Diseases, Functional / etiology Diarrhea / etiology* Dysentery, Bacillary / complications Gastroenteritis / complications* Humans Middle Aged Retrospective Studies Salmonella Infections / complications Shigella sonnei |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts |
| Comments/Corrections | |
Comment In:
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Clin Med. 2001 Mar-Apr;1(2):156
[PMID:
11333465
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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