| Postinfectious vasculopathy with evolution to moyamoya syndrome. | |
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MedLine Citation:
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PMID: 15654044 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Parainfectious vascular events are a known complication of bacterial meningitis, typically occurring within two weeks of disease onset. Delayed vascular complications are rare. We present a case of progressive vasculopathy following bacterial meningitis. CASE DESCRIPTION: A 20 year old woman developed progressive vasculopathy after successful treatment of pneumococcal meningitis. Within eight months of her infection, angiography revealed the appearance of moyamoya syndrome. Despite aggressive immunomodulation and anticoagulation, she had multiple strokes. Autopsy confirmed severe narrowing of proximal cerebral vasculature with absence of inflammation or atherosclerosis. CONCLUSIONS: The inflammation and subsequent postinfectious autoimmune response associated with meningitis can lead to a progressive vasculopathy and may represent a pathophysiologic mechanism for the arterial occlusions seen in moyamoya syndrome. |
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Authors:
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T Czartoski; D Hallam; J M Lacy; M R Chun; K Becker |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 76 ISSN: 0022-3050 ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-01-17 Completed Date: 2005-02-15 Revised Date: 2008-11-20 |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 256-9 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Washington School of Medicine, Harborview Medical Center, Seattle, WA 98104-249, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autopsy Cerebrovascular Disorders / complications, etiology*, pathology Fatal Outcome Female Humans Immunologic Factors / therapeutic use Meningitis, Pneumococcal / complications*, drug therapy Moyamoya Disease / etiology*, pathology Stroke / etiology* |
| Grant Support | |
ID/Acronym/Agency:
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K02 NS02160-01 NST/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Immunologic Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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