| Postictal serum levels of antiepileptic drugs for detection of noncompliance. | |
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MedLine Citation:
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PMID: 14527489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Medication noncompliance (NC) is thought to be a major cause of insufficient seizure control. In an explorative study we investigated whether postictal serum levels (PISLs) of antiepileptic drugs (AEDs) are a reliable indicator of NC. Young adults with epilepsy on a stable AED regimen were asked to contact medical service as soon as possible when a seizure occurred to obtain serum levels of their AEDs. PISLs were compared with the mean value of two routine serum levels of the same medication. PISLs lower than 50% of the individual reference value were regarded as an indicator of NC. PISL samples in 61 seizures of 52 patients treated mainly with carbamazepine, valproic acid, or lamotrigine were evaluated. A drop in serum levels >50% indicating NC was noted in 44.3% of the seizures. Determination of PISLs seems to be a simple and useful method for detecting or ruling out irregular intake patterns as a cause of "breakthrough" seizures. |
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Authors:
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U Specht; H Elsner; T W May; B Schimichowski; R Thorbecke |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Epilepsy & behavior : E&B Volume: 4 ISSN: 1525-5050 ISO Abbreviation: Epilepsy Behav Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-10-06 Completed Date: 2003-12-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100892858 Medline TA: Epilepsy Behav Country: United States |
Other Details:
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Languages: eng Pagination: 487-95 Citation Subset: IM |
Affiliation:
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Rehabilitation Unit and Clinic Mara 1, Bethel Epilepsy Center, Maraweg 21, D-33617 Bielefeld, Germany. usp@mara.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anticonvulsants / blood*, pharmacokinetics, therapeutic use* Female Humans Male Recurrence Seizures / blood*, physiopathology Treatment Refusal* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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