Document Detail

Posthysterectomy bleeding after ketorolac tromethamine and spinal anesthesia. A case report.
MedLine Citation:
PMID:  10845179     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Ketorolac is a very useful medication in gynecologic surgery, providing pain relief and less narcotic use. This greatly shortens the recovery time and length of hospital stay. As with other nonsteroidal antiinflammatories, gynecologists are aware of the potential for bleeding problems from ketorolac, yet those bleeding complications have rarely been seen in gynecology and have not been previously reported in the gynecologic literature. A recent case demonstrates the serious complication that can occur when ketorolac inhibits platelet function postoperatively. CASE: A 36-year-old woman began bleeding intraabdominally shortly after an otherwise-unremarkable vaginal hysterectomy done under spinal anesthesia. CONCLUSION: A literature review suggests that this complication is highly associated with nongeneral anesthesia surgery, such as spinal, epidural and conscious sedation. This fact, however, has not been published in the gynecologic literature and is not well known to gynecologists. Pending further elucidation of this problem, avoidance of ketorolac perioperatively with nongeneral anesthesia cases should be considered.
R Lehman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  45     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-09-20     Completed Date:  2000-09-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  431-4     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Washington School of Medicine, Spokane, USA.
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MeSH Terms
Anesthesia, Spinal*
Anti-Inflammatory Agents / adverse effects*
Ketorolac Tromethamine / adverse effects*
Platelet Aggregation Inhibitors / adverse effects*
Postoperative Hemorrhage / chemically induced*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Platelet Aggregation Inhibitors; 0/Steroids; 74103-07-4/Ketorolac Tromethamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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