Document Detail

Posthypoxic disturbances in glutamatergic signal transduction in rat brain neurons: correction effect of preconditioning.
MedLine Citation:
PMID:  12910303     Owner:  NLM     Status:  MEDLINE    
Severe 3-h hypobaric hypoxia was followed by impairment of Ca(2+)-mediated glutamatergic signal transduction in the posthypoxic period (no less than 72 h). This impairment manifested in changes in the calcium response to glutamate application in slices of rat brain cortex. Moderate hypoxic preconditioning prevented these disturbances developed over the first day after sever hypoxia.
O L Miller; D G Semenov; M O Samoilov
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  135     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-08-11     Completed Date:  2004-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  340-2     Citation Subset:  IM    
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
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MeSH Terms
Anoxia / metabolism*
Calcium / metabolism*
Glutamic Acid / metabolism*
Ischemic Preconditioning*
Neurons / metabolism*
Rats, Wistar
Signal Transduction / physiology*
Reg. No./Substance:
56-86-0/Glutamic Acid; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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