| Postexposure immunotherapy of simian immunodeficiency virus (SIV) infected rhesus with an SIV immunogen. | |
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MedLine Citation:
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PMID: 2547966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An inactivated whole simian immunodeficiency virus (SIV) immunogen given to healthy, seropositive rhesus macaques 4 months after infection had no effect on the humoral immune response to SIV, the presence of antigenemia, cell-associated viremia, or disease course. Further immunotherapeutic trials in this highly susceptible animal model should be carried out sooner after exposure, before significant loss of CD4 cells has occurred. The SIV infected macaque model will continue to serve an essential role in development and testing of anti-AIDS drugs and immunogens. |
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Authors:
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M B Gardner; M Jennings; J R Carlson; N Lerche; T McGraw; P Luciw; P Marx; N Pedersen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of medical primatology Volume: 18 ISSN: 0047-2565 ISO Abbreviation: J. Med. Primatol. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-09-08 Completed Date: 1989-09-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0320626 Medline TA: J Med Primatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 321-8 Citation Subset: IM; X |
Affiliation:
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Department of Medical Pathology, University of California, Davis. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Viral / biosynthesis Disease Models, Animal Immunity, Cellular Immunotherapy* / veterinary Macaca / immunology* Macaca mulatta / immunology* Monkey Diseases / immunology*, therapy Retroviridae Infections / immunology, therapy, veterinary* Simian immunodeficiency virus / immunology* Viremia / veterinary |
| Grant Support | |
ID/Acronym/Agency:
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A1-62559//PHS HHS; RR-00169/RR/NCRR NIH HHS; UO1-A125900//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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