| Postexercise alpha-adrenergic receptor hyporesponsiveness in hypertensive rats is due to nitric oxide. | |
| | |
MedLine Citation:
|
PMID: 11893598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We tested the hypothesis that a single bout of dynamic exercise produces a postexercise hypotension (PEH) and alpha(1)-adrenergic receptor hyporesponsiveness in spontaneously hypertensive rats (SHR). The postexercise alpha(1)-adrenergic receptor hyporesponsiveness is due to an enhanced buffering of vasoconstriction by nitric oxide. Male (n = 8) and female (n = 5) SHR were instrumented with a Doppler ultrasonic flow probe around the femoral artery. Distal to the flow probe, a microrenathane catheter was inserted into a branch of the femoral artery for the infusion of the alpha(1)-adrenergic receptor agonist phenylephrine (PE). A microrenathane catheter was inserted into the descending aorta via the left common carotid artery for measurements of arterial pressure (AP) and heart rate. Dose-response curves to PE (3.8 x 10(-3) - 1.98 x 10(-2)microg/kHz) were generated before and after a single bout of dynamic exercise. Postexercise AP was reduced in male (13 +/- 3 mmHg) and female SHR (18 +/- 7 mmHg). Postexercise vasoconstrictor responses to PE were reduced in males due to an enhanced influence of nitric oxide. However, in females, postexercise vasoconstrictor responses to PE were not altered. Results suggest that nitric oxide- mediated alpha(1)-adrenergic receptor hyporesponsiveness contributes to PEH in male but not female SHR. |
| | |
Authors:
|
Sumangala P Rao; Heidi L Collins; Stephen E DiCarlo |
Related Documents
:
|
19608358 - The effect of recombinant aminopeptidase a (apa) on hypertension in pregnant spontaneou... 18075218 - Interaction between alpha-linolenic acid-enriched oil and ace inhibitor concerning the ... 2560788 - Effect of enalapril on aortic smooth muscle cell polyploidy in the spontaneously hypert... 8762208 - Low magnesium enhances the pro-arrhythmic effect of low potassium in the hypertrophied ... 12107398 - Angiotensin converting enzyme inhibition and dihydropyridine calcium channel blockade i... 8468768 - Regional effects and mechanism of positive end-expiratory pressure in early adult respi... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 282 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2002 Apr |
Date Detail:
|
Created Date: 2002-03-14 Completed Date: 2002-04-16 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: R960-8 Citation Subset: IM |
Affiliation:
|
Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic alpha-Agonists
/
pharmacology Animals Blood Flow Velocity / physiology Blood Pressure / physiology Female Femoral Artery / physiology Heart Rate / physiology Hypertension / metabolism* Laser-Doppler Flowmetry Male Nitric Oxide / metabolism* Phenylephrine / pharmacology Physical Exertion / physiology* Rats Receptors, Adrenergic, alpha-1 / metabolism* Sex Factors Vasoconstriction / drug effects, physiology |
| Grant Support | |
ID/Acronym/Agency:
|
HL-58414/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic alpha-Agonists; 0/Receptors, Adrenergic, alpha-1; 10102-43-9/Nitric Oxide; 59-42-7/Phenylephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Enhanced vascular effects of the Ca(2+) channel agonist Bay K 8644 in pregnant rabbits.
Next Document: Multiple dilator pathways in skeletal muscle contraction-induced arteriolar dilations.