Document Detail


Posterior urethral valves.
MedLine Citation:
PMID:  19838598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The most common cause of lower urinary tract obstruction in male infants is posterior urethral valves. Although the incidence has remained stable, the neonatal mortality for this disorder has improved due to early diagnosis and intensive neonatal care, thanks in part to the widespread use of prenatal ultrasound evaluations. In fact, the most common reason for the diagnosis of posterior urethral valves presently is the evaluation of infants for prenatal hydronephrosis. Since these children are often diagnosed early, the urethral obstruction can be alleviated rapidly through catheter insertion and eventual surgery, and their metabolic derangements can be normalized without delay, avoiding preventable infant mortality. Of the children that survive, however, early diagnosis has not had much effect on their long-term prognosis, as 30% still develop renal insufficiency before adolescence. A better understanding of the exact cause of the congenital obstruction of the male posterior urethra, prevention of postnatal bladder and renal injury, and the development of safe methods to treat urethral obstruction prenatally (and thereby avoiding the bladder and renal damage due to obstructive uropathy) are the goals for the care of children with posterior urethral valves[1].
Authors:
Steve J Hodges; Bhavin Patel; Gordon McLorie; Anthony Atala
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-10-14
Journal Detail:
Title:  TheScientificWorldJournal     Volume:  9     ISSN:  1537-744X     ISO Abbreviation:  ScientificWorldJournal     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-19     Completed Date:  2009-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101131163     Medline TA:  ScientificWorldJournal     Country:  England    
Other Details:
Languages:  eng     Pagination:  1119-26     Citation Subset:  IM    
Affiliation:
Department of Urology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. shodges@wfubmc.edu
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MeSH Terms
Descriptor/Qualifier:
Fetal Diseases / diagnosis
Humans
Male
Prenatal Diagnosis
Prognosis
Urethra / abnormalities
Urethral Obstruction / congenital*,  diagnosis,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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