| Posterior urethral valves: preliminary observations on the significance of plasma Renin activity as a prognostic marker. | |
| | |
MedLine Citation:
|
PMID: 15643266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: A significant number of children with posterior urethral valves (PUVs) have chronic renal failure due to tubulointerstitial damage. Activation of the renin-angiotensin system is known to inflict this injury. We investigated the role of plasma renin activity (PRA) in patients with PUVs and sought to establish a relationship between renal damage and PRA. MATERIALS AND METHODS: The records of patients with PUVs were reviewed regarding the time of valve ablation, serum creatinine, scars, grade of reflux and glomerular filtration rate (GFR). PRA was measured before and after valve ablation. RESULTS: A total of 25 patients had PUVs (mean age 3.2 +/- 2.4 years, mean period of observation 4.5 +/- 1.2 years). Mean PRA was increased before valve ablation in all patients irrespective of age, and decreased after ablation. Of 25 patients 14 (56%) had renal damage, with a mean PRA of 36 +/- 4.5 ng/ml per hour compared to 26 +/- 8.2 ng/ml per hour in patients with normal renal function (chi-square 4.2 p = 0.01). Of the 14 patients with renal damage 9 (64%) had normal GFR at age 1 year but increased PRA. Of these 14 patients the accepted criteria for renal damage of increased serum creatinine, high grade reflux, scars and decreasing GFR were present in only 6 (43%), 3 (21%), 2 (14%) and 4 (29%), respectively. PRA was increased in all 14 cases. CONCLUSIONS: PRA was increased before valve ablation and decreased after ablation. It is increased in patients with early renal damage. Our preliminary observations indicate that PRA may be helpful in identifying patients with early renal damage. |
| | |
Authors:
|
Minu Bajpai; Akshay Pratap; Madhavi Tripathi; C S Bal |
Related Documents
:
|
17706566 - Fibrotic heart-valve reactions to dopamine-agonist treatment in parkinson's disease. 17091326 - Echocardiographic follow-up of children with supravalvular aortic stenosis. 9852886 - Quality of life in patients with bioprostheses and mechanical prostheses. evaluation of... 2330866 - Safety and utility of transesophageal echocardiography in the critically ill patient. 265446 - Otolaryngeal allergy in wellington. 1971-1975. 20865356 - Restless legs and substantia nigra hypoechogenicity are common features in friedreich's... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of urology Volume: 173 ISSN: 0022-5347 ISO Abbreviation: J. Urol. Publication Date: 2005 Feb |
Date Detail:
|
Created Date: 2005-01-11 Completed Date: 2005-03-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376374 Medline TA: J Urol Country: United States |
Other Details:
|
Languages: eng Pagination: 592-4 Citation Subset: AIM; IM |
Affiliation:
|
Departments of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi-110029, India. bajpai2@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biological Markers
/
blood Child Child, Preschool Follow-Up Studies Humans Infant Male Prognosis Renin / blood* Urethra / abnormalities* |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An embryological study of fetal development of the rectourethralis muscle--does it really exist?
Next Document: Long-term outcome of visual internal urethrotomy for the management of pediatric urethral strictures...