Document Detail

Posterior urethral valves in siblings.
MedLine Citation:
PMID:  2648659     Owner:  NLM     Status:  MEDLINE    
The etiology and incidence of posterior urethral valves is unknown. We report on a pair of non-twin siblings with identical pathology stemming from type I posterior urethral valves as well as discordance in a pair of monozygotic twins. Familial posterior urethral valves have been reported before in both twin and non-twin siblings. The occurrence of identical pathology in non-twin siblings suggests the possibility of an inherited trait as does its occurrence in identical twins. However, non-identical clinical manifestation is as common as is identical presentation in both groups. There are also instances of discordance in monozygotic twins suggesting the possibility of a random mutation. As such, we recommend urologic evaluation of the male siblings of affected patients with posterior urethral valves. Further prospective and retrospective analyses are needed to define the genetic etiology of valves.
J V Thomalla; M E Mitchell; R A Garett
Related Documents :
25423569 - Pregnancy outcomes and relationship to treatment adequacy in women treated early for co...
25481579 - The site of attachment of umbilical cord and branching pattern of umbilical arteries wi...
25162249 - Prenatal management of monoamniotic twin pregnancies.
5690279 - Genetic control of drug levels in man: antipyrine.
8349859 - Psoriasis in australian twins.
25358519 - An integrated model with classification criteria to predict small-for-gestational fetus...
945079 - The regulatory effect of estrogens on fetal growth. iv. brain development in growth acc...
25423569 - Pregnancy outcomes and relationship to treatment adequacy in women treated early for co...
17607729 - Lead induced malformations in embryos of the african catfish clarias gariepinus (burche...
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Urology     Volume:  33     ISSN:  0090-4295     ISO Abbreviation:  Urology     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-05-11     Completed Date:  1989-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  291-4     Citation Subset:  IM    
Department of Urology, James Whitcomb Riley Hospital for Children, Indiana University Medical Center, Indianapolis.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Diabetic Nephropathies / complications
Family Health*
Hydronephrosis / complications
Infant, Newborn
Infant, Premature*
Twins, Monozygotic*
Urethra / abnormalities*,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Successful implantation of penile prostheses in organ transplant patients.
Next Document:  General principles of fluid therapy in small animal medicine.