Document Detail


Posterior urethral valves in siblings.
MedLine Citation:
PMID:  2648659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The etiology and incidence of posterior urethral valves is unknown. We report on a pair of non-twin siblings with identical pathology stemming from type I posterior urethral valves as well as discordance in a pair of monozygotic twins. Familial posterior urethral valves have been reported before in both twin and non-twin siblings. The occurrence of identical pathology in non-twin siblings suggests the possibility of an inherited trait as does its occurrence in identical twins. However, non-identical clinical manifestation is as common as is identical presentation in both groups. There are also instances of discordance in monozygotic twins suggesting the possibility of a random mutation. As such, we recommend urologic evaluation of the male siblings of affected patients with posterior urethral valves. Further prospective and retrospective analyses are needed to define the genetic etiology of valves.
Authors:
J V Thomalla; M E Mitchell; R A Garett
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Urology     Volume:  33     ISSN:  0090-4295     ISO Abbreviation:  Urology     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-05-11     Completed Date:  1989-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  291-4     Citation Subset:  IM    
Affiliation:
Department of Urology, James Whitcomb Riley Hospital for Children, Indiana University Medical Center, Indianapolis.
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MeSH Terms
Descriptor/Qualifier:
Diabetic Nephropathies / complications
Family*
Family Health*
Humans
Hydronephrosis / complications
Infant, Newborn
Infant, Premature*
Male
Twins*
Twins, Monozygotic*
Urethra / abnormalities*,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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