Document Detail


Posterior reversible encephalopathy syndrome as a complication of acute lupus activity.
MedLine Citation:
PMID:  19128872     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We aimed to describe the clinical and imaging characteristics; associated risk factors and neurological outcome of posterior reversible encephalopathy syndrome (PRES) in patients with systemic lupus erythematosus (SLE). METHODS: From October 2001 to January 2007, we identified patients with SLE and the criteria for PRES in our institution, which is a tertiary-care referral center for patients with SLE; the patients were evaluated at baseline and followed to determine the clinical outcome. RESULTS: We identified 22 episodes of PRES in 21 patients; 20 (95.2%) were women, mean age of onset was 24.9+/-8.6 years, all patients had high systemic activity (SLEDAI scores from 12 to 39). Acute hypertension was observed in 18 episodes (81.8%), and renal failure in 16 (72.7%); only 3 patients were on cyclophosphamide at the time of the onset of PRES. Persistent neurological deficit was observed in 2 cases; one patient died during the acute episode. CONCLUSIONS: PRES is a central nervous system syndrome that is observed in SLE patients. It was associated mainly to high systemic activity, acute hypertension, and renal failure. Although reversibility is common, residual neurological damage may be observed.
Authors:
José Fidel Baizabal-Carvallo; Héctor Manuel Barragán-Campos; Héctor Javier Padilla-Aranda; Marlene Alonso-Juarez; Bruno Estañol; Carlos Cantú-Brito; Guillermo García-Ramos
Publication Detail:
Type:  Journal Article     Date:  2009-01-06
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  111     ISSN:  1872-6968     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-07     Completed Date:  2009-07-01     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  359-63     Citation Subset:  IM    
Affiliation:
Department of Neurology and Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, México City, Mexico. baicarjf@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain Diseases, Metabolic / epidemiology,  etiology*,  pathology*,  physiopathology
Cyclophosphamide / therapeutic use
Female
Humans
Hypertension / epidemiology,  etiology*
Kidney Failure / epidemiology,  etiology*
Lupus Erythematosus, Systemic / complications*,  pathology
Magnetic Resonance Imaging
Male
Young Adult
Chemical
Reg. No./Substance:
50-18-0/Cyclophosphamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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