Document Detail

Posterior leukoencephalopathy in association with the tumour lysis syndrome in acute lymphoblastic leukaemia--a case with clinicopathological correlation.
MedLine Citation:
PMID:  12774751     Owner:  NLM     Status:  MEDLINE    
We report a case and autopsy findings of posterior leukoencephalopathy (PL) developing during induction chemotherapy for B-cell acute lymphoblastic leukaemia (B-ALL) complicated by tumour lysis syndrome. PL may present with seizures, headache, altered mental status and occipital blindness, associated with transient parieto-occipital abnormalities on neuro-imaging studies. Precipitants include immunosuppressive agents, renal insufficiency, hypertension and fluid retention. It has also been reported in association with pre-eclamptic and eclamptic states, nephrotic syndrome and following liver and bone marrow transplantation. Only rare cases of PL developing during treatment for haematological malignancy have been reported and to our knowledge it has not been previously reported in association with tumour lysis syndrome. Since the condition is generally regarded as being fully reversible few autopsy findings have been reported.
M J Greenwood; A J Dodds; R Garricik; M Rodriguez
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  44     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-05-28     Completed Date:  2003-12-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  England    
Other Details:
Languages:  eng     Pagination:  719-21     Citation Subset:  IM    
Leukemia/Bone Marrow Transplant Program Of British Columbia, Vancouver General Hospital, Vancouver, BC, Canada.
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MeSH Terms
Middle Aged
Neuromuscular Diseases / complications*,  diagnosis,  mortality
Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*,  diagnosis,  mortality
Tumor Lysis Syndrome / complications*,  diagnosis,  mortality

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