Document Detail


Posterior cortical atrophy.
MedLine Citation:
PMID:  22265212     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Posterior cortical atrophy (PCA) is a neurodegenerative syndrome that is characterised by progressive decline in visuospatial, visuoperceptual, literacy, and praxic skills. The progressive neurodegeneration affecting parietal, occipital, and occipitotemporal cortices that underlies PCA is attributable to Alzheimer's disease in most patients. However, alternative underlying causes, including dementia with Lewy bodies, corticobasal degeneration, and prion disease, have also been identified, and not all patients with PCA have atrophy on clinical imaging. This heterogeneity has led to inconsistencies in diagnosis and terminology and difficulties in comparing studies from different centres, and has restricted the generalisability of findings from clinical trials and investigations of factors that drive phenotypic variability. Important challenges remain, including the identification of factors associated not only with the selective vulnerability of posterior cortical regions but also with the young age of onset of PCA. Greater awareness of the syndrome and agreement over the correspondence between syndrome-level and disease-level classifications are needed to improve diagnostic accuracy, clinical management, and the design of research studies.
Authors:
Sebastian J Crutch; Manja Lehmann; Jonathan M Schott; Gil D Rabinovici; Martin N Rossor; Nick C Fox
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Lancet neurology     Volume:  11     ISSN:  1474-4465     ISO Abbreviation:  Lancet Neurol     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-23     Completed Date:  2012-03-09     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101139309     Medline TA:  Lancet Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  170-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Atrophy
Cerebral Cortex / pathology*,  physiopathology*
Cognition Disorders / pathology,  physiopathology
Female
Humans
Neurodegenerative Diseases* / classification,  diagnosis,  etiology,  physiopathology
Syndrome
Grant Support
ID/Acronym/Agency:
G0601846//Medical Research Council; K23 AG031861/AG/NIA NIH HHS; K23-AG031861/AG/NIA NIH HHS; //Medical Research Council
Comments/Corrections

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