Document Detail

Posterior cortical atrophy: variant of Alzheimer's disease? A case series with PET findings.
MedLine Citation:
PMID:  15654552     Owner:  NLM     Status:  MEDLINE    
Nine patients with posterior cortical atrophy (PCA), a rare degenerative brain disease of unclear etiology and nosology, were followed over a mean time of 7.4 years. The mean age at onset was low (56.2 years). At onset, eight patients had visuo-spatial and eight had memory impairment. A minority showed early signs of occipital lobe involvement with visual agnosia or hemianopia. Eight patients developed dementia after a mean course of five years. 18F-FDG-PET data of six patients were analysed with statistical parametric mapping. They showed hypometabolism centred on the lateral and medial parietal associative cortex, with variable involvement of the adjacent temporal and occipital associative cortex. A minority showed involvement of the frontal lobes, possibly related to deafferenting of areas related to the control of eye movements. Atrophy and hypometabolism were markedly asymmetric in a subset of cases. Autopsy was performed in one patient. Presenile onset, location, and asymmetry of atrophy suggest that PCA represents a biologically separable variant of Alzheimer's disease.
Klaus Schmidtke; Michael Hüll; Jochen Talazko
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology     Volume:  252     ISSN:  0340-5354     ISO Abbreviation:  J. Neurol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-17     Completed Date:  2005-04-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  27-35     Citation Subset:  IM    
Center for Geriatric Medicine and Gerontology Freiburg, Lehener Strasse 88, 79106 Freiburg, Germany.
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MeSH Terms
Age of Onset
Agnosia / pathology,  physiopathology,  radionuclide imaging
Alzheimer Disease / pathology*,  physiopathology*,  radionuclide imaging
Atrophy / pathology*,  physiopathology*,  radiography
Cerebral Cortex / pathology,  physiopathology*,  radionuclide imaging
Diagnosis, Differential
Disease Progression
Energy Metabolism / physiology
Hemianopsia / pathology,  physiopathology,  radionuclide imaging
Magnetic Resonance Imaging
Memory Disorders / pathology,  physiopathology,  radionuclide imaging
Middle Aged
Occipital Lobe / pathology,  physiopathology,  radionuclide imaging
Parietal Lobe / pathology,  physiopathology,  radionuclide imaging
Positron-Emission Tomography
Retrospective Studies
Time Factors

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