| Posterior cortical atrophy: variant of Alzheimer's disease? A case series with PET findings. | |
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MedLine Citation:
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PMID: 15654552 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nine patients with posterior cortical atrophy (PCA), a rare degenerative brain disease of unclear etiology and nosology, were followed over a mean time of 7.4 years. The mean age at onset was low (56.2 years). At onset, eight patients had visuo-spatial and eight had memory impairment. A minority showed early signs of occipital lobe involvement with visual agnosia or hemianopia. Eight patients developed dementia after a mean course of five years. 18F-FDG-PET data of six patients were analysed with statistical parametric mapping. They showed hypometabolism centred on the lateral and medial parietal associative cortex, with variable involvement of the adjacent temporal and occipital associative cortex. A minority showed involvement of the frontal lobes, possibly related to deafferenting of areas related to the control of eye movements. Atrophy and hypometabolism were markedly asymmetric in a subset of cases. Autopsy was performed in one patient. Presenile onset, location, and asymmetry of atrophy suggest that PCA represents a biologically separable variant of Alzheimer's disease. |
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Authors:
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Klaus Schmidtke; Michael Hüll; Jochen Talazko |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurology Volume: 252 ISSN: 0340-5354 ISO Abbreviation: J. Neurol. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-01-17 Completed Date: 2005-04-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0423161 Medline TA: J Neurol Country: Germany |
Other Details:
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Languages: eng Pagination: 27-35 Citation Subset: IM |
Affiliation:
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Center for Geriatric Medicine and Gerontology Freiburg, Lehener Strasse 88, 79106 Freiburg, Germany. klaus.schmidtke@uniklinik-freiburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age of Onset Agnosia / pathology, physiopathology, radionuclide imaging Alzheimer Disease / pathology*, physiopathology*, radionuclide imaging Atrophy / pathology*, physiopathology*, radiography Cerebral Cortex / pathology, physiopathology*, radionuclide imaging Diagnosis, Differential Disease Progression Energy Metabolism / physiology Female Hemianopsia / pathology, physiopathology, radionuclide imaging Humans Magnetic Resonance Imaging Male Memory Disorders / pathology, physiopathology, radionuclide imaging Middle Aged Occipital Lobe / pathology, physiopathology, radionuclide imaging Parietal Lobe / pathology, physiopathology, radionuclide imaging Positron-Emission Tomography Retrospective Studies Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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