Document Detail


Posterior Reversible Encephalopathy Syndrome (PRES) in 5-year-old girl with nephrotic syndrome.
MedLine Citation:
PMID:  20588234     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Posterior Reversible Encephalopathy Syndrome (PRES) is a rare complication of nephrotic syndrome in children. This clinical condition is caused by localized brain angioedema mostly in parieto-occipital region and results in dramatic and acute features as sudden loss of consciousness, epileptic paroxysms, strong headache or visual disturbances. Uncontrolled hypertension often participates in PRES development.
CASE: We present the case of a 5-year-old girl treated for relapse of nephrotic syndrome.
RESULTS: At the time of edema regression and weight reduction, a sudden loss of consciousness and worsening of hypertension occurred. Brain MRI demonstrated extended multifocal changes strongly suspicious of encephalitis. After exclusion of herpetic encephalitis, the clinical picture was classified as PRES. Successful antihypertensive treatment led to general improvement of the girl's health within 48 hours and resolution of MRI brain hyperintensities occurred within the next three months.
CONCLUSIONS: The aim of our case report is to us remind of possible development of PRES at the time of edema regression in nephrotic syndrome.
Authors:
Pavel Kabicek; Stepan Sulek; Zdenek Seidl; Manuela Vaneckova; Edita Kabickova; Vaclav Vobruba; Laszlo Wenchich; Jiri Zeman
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  31     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-23     Completed Date:  2010-10-08     Revised Date:  2011-02-07    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  297-300     Citation Subset:  IM    
Affiliation:
Department of Pediatrics and Adolescent Medicine, General University Hospital and 1st Faculty of Medicine, Charles University Prague, Czech Republic. p.kabicek@post.cz
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MeSH Terms
Descriptor/Qualifier:
Antihypertensive Agents / therapeutic use
Child
Female
Humans
Magnetic Resonance Imaging
Nephrotic Syndrome / complications*,  drug therapy
Posterior Leukoencephalopathy Syndrome / complications*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents
Comments/Corrections
Comment In:
Neuro Endocrinol Lett. 2010;31(6):728; author reply 729-30   [PMID:  21196919 ]

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