Document Detail

Postdated versus usual delayed antibiotic prescriptions in primary care: Reduction in antibiotic use for acute respiratory infections?
MedLine Citation:
PMID:  20944049     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether postdating delayed antibiotic prescriptions results in a further decrease (over usual delayed prescriptions) in antibiotic use.
DESIGN: Randomized controlled trial.
SETTING: A small rural town in Newfoundland and Labrador.
PARTICIPANTS: A total of 149 consecutive adult primary care patients who presented with acute upper respiratory tract infections.
INTERVENTION: Delayed prescriptions for patients who might require antibiotics were randomly dated either the day of the office visit (ie, the usual group) or 2 days later (ie, the postdated group).
MAIN OUTCOME MEASURES: Whether or not the prescriptions were filled and the time it took for the patients to fill the prescriptions were noted by the 4 local pharmacies and relayed to the investigators.
RESULTS: In total, 149 delayed antibiotic prescriptions were written, 1 per patient. Of the 74 usual delayed prescriptions given out, 32 (43.2%) were filled; of the 75 postdated delayed prescriptions given out, 33 (44.0%) were filled. Sixteen patients from each group filled their delayed prescriptions earlier than the recommended 48 hours. Statistical analyses-χ² tests to compare the rates of antibiotic use between the 2 groups and t tests to compare the mean time to fill the prescription between the 2 groups-indicated that these results were not significant (P > .05).
CONCLUSION: Although delayed prescriptions reduce the rate of antibiotic use, postdating the delayed prescription does not seem to lead to further reduction in use.
Graham Worrall; Angela Kettle; Wendy Graham; Jim Hutchinson
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Canadian family physician Médecin de famille canadien     Volume:  56     ISSN:  1715-5258     ISO Abbreviation:  Can Fam Physician     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-14     Completed Date:  2012-04-05     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0120300     Medline TA:  Can Fam Physician     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1032-6     Citation Subset:  IM    
Department of Family Medicine at Memorial University of Newfoundland in St John’s.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Drug Prescriptions / statistics & numerical data*
Respiratory Tract Infections / drug therapy*
Time Factors
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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