| Postconditioning with α7nAChR Agonist Attenuates Systemic Inflammatory Response to Myocardial Ischemia-Reperfusion Injury in Rats. | |
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MedLine Citation:
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PMID: 22391744 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The inflammatory response plays a major role in ischemia-reperfusion injury (IRI). Considering that cholinergic stimulation can inhibit inflammatory response through the cholinergic anti-inflammatory pathway (CAP) and the α subunit-containing nicotinic acetylcholine receptor(α7nAChR) expressed by immune cells is an important component of CAP, we assessed the effect of postconditioning with α7nAChR agonist on systemic inflammatory response during the myocardial ischemia-reperfusion process in an in vivo rat model. Thirty Sprague Dawley rats were randomly divided into three groups: sham group, control group, and postconditioning with α7nAChR agonist group (PP group). In the groups other than the sham group, the left anterior descending coronary artery was ligated for 30 min followed by a 180-min reperfusion. At the end of the experiment, the serum levels of troponin I, tumor necrosis factor α, interleukin-6, and high-mobility group box 1 were assayed, and the infarct size was assessed. The results showed that postconditioning with α7nAChR agonist significantly attenuated the systemic inflammatory response to myocardial IRI, as evidenced by decreased serum levels of tumor necrosis factor α and high-mobility group box 1. Also, this treatment protected against myocardial IRI, as shown by reduced infarct size and serum troponin I level. |
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Authors:
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Jun Xiong; Yu-Jing Yuan; Fu-Shan Xue; Qiang Wang; Yi Cheng; Rui-Ping Li; Xu Liao; Jian-Hua Liu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-4 |
Journal Detail:
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Title: Inflammation Volume: - ISSN: 1573-2576 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600105 Medline TA: Inflammation Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Anesthesiology, Tongren Hospital, Capital Medical University, Beijing, 100730, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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