| Postconditioning in man. | |
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MedLine Citation:
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PMID: 17522975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute myocardial infarction is the leading cause of morbidity and mortality in industrialized countries. Ischemic postconditioning, that consists of repeated brief episodes of ischemia-reperfusion performed just after reflow following a prolonged ischemic insult, dramatically reduces infarct size in animal models. Recent data indicate that it might involve the activation of the PI3-kinase-Akt-eNOS as well as PKC signalling pathways and inhibition of the opening of the permeability transition pore. A recent clinical study demonstrated that postconditioning protects the human heart. Repeated brief episodes of inflation-deflation of the angioplasty balloon performed immediately after re-opening of the culprit coronary artery reduced infarct size by 36%. Additional studies are required to determine whether infarct size limitation by postconditioning would improve functional recovery as well as patient's outcome. Further research is needed to find new pharmacological agents that would mimick postconditioning in order to treat all patients with ongoing acute myocardial infarction. |
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Authors:
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Hélène Thibault; Christophe Piot; Michel Ovize |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Heart failure reviews Volume: 12 ISSN: 1382-4147 ISO Abbreviation: Heart Fail Rev Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-07-19 Completed Date: 2007-11-08 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9612481 Medline TA: Heart Fail Rev Country: United States |
Other Details:
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Languages: eng Pagination: 245-8 Citation Subset: IM |
Affiliation:
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Hôpital Cardiologique and Pneumologique Louis Pradel, Hospices Civils de Lyon, 59 Boulevard Pinel, 69394 Lyon cedex 03, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Phosphatidylinositol 3-Kinase
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metabolism Humans Ischemic Preconditioning, Myocardial* Myocardial Infarction / complications*, physiopathology Myocardial Ischemia / etiology, prevention & control* Myocardium Nitric Oxide Synthase Protein Kinase C Proto-Oncogene Proteins c-akt / metabolism Signal Transduction* Time Factors |
| Chemical | |
Reg. No./Substance:
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EC 1.14.13.39/Nitric Oxide Synthase; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 2.7.11.13/Protein Kinase C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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