Document Detail


Postconditioning fails to prevent radial artery endothelial dysfunction induced by ischemia and reperfusion: evidence from a human in vivo study.
MedLine Citation:
PMID:  16900245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Animal studies have shown that, as compared with unrestricted reperfusion, exposure to brief periods of controlled ischemia (postconditioning) at the end of a prolonged ischemia reduces the extent of tissue damage. We set out to test whether postconditioning can prevent endothelial dysfunction induced by ischemia and reperfusion in a human in vivo model. Ten healthy young non-smoking volunteers were enrolled in this cross-over, controlled, investigator-blinded study. Subjects were exposed to 15 min of forearm ischemia followed by either unrestricted reperfusion or postconditioning (3 periods of 20 s of ischemia separated by 10 s of reperfusion). Endothelium-dependent flow-mediated dilation (FMD) was measured at the level of the radial artery before and after ischemia (with or without postconditioning). Forearm ischemia blunted FMD in both study visits (unrestricted reperfusion visit: before ischemia, 7.7% +/- 1.3%; after ischemia, 2.5% +/- 1.4%; and postconditioning visit: before, 7.3% +/- 1.2%; after, 2.6 +/- 1.6%; P < 0.05 for both, P = not significant (NS) between visits). In contrast with data from animal studies, postconditioning (20 s ischemia-- 10 s reperfusion repeated 3 times) does not limit post-ischemic endothelial dysfunction in this human in vivo model. Further human studies are necessary to evaluate other reperfusion protocols in an attempt to limit post-ischemic tissue damage.
Authors:
Saverio Dragoni; Giuseppe Di Stolfo; Silvia Sicuro; Monica Lisi; John D Parker; Sandro Forconi; Tommaso Gori
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  84     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-08-10     Completed Date:  2006-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  611-5     Citation Subset:  IM    
Affiliation:
Department of Internal, Cardiovascular and Geriatric Medicine, Azienda Ospedaliera Universitaria Senese, University of Siena, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Arm / blood supply
Brachial Artery / physiology
Cross-Over Studies
Double-Blind Method
Endothelium, Vascular / injuries*
Humans
Ischemia / therapy*
Ischemic Preconditioning, Myocardial / methods*
Male
Middle Aged
Radial Artery / anatomy & histology,  injuries*
Regional Blood Flow
Reperfusion / adverse effects*
Reperfusion Injury / prevention & control*
Treatment Failure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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